Basic Information
ID: ALA4192661
Type: Functional
Description: Antagonist activity at His6-tagged NK1 receptor (unknown origin) expressed in CHO cells assessed as inhibition of substance-P-induced IP1 accumulation at 10'-5 M preincubated for 10 mins followed by substance-P addition measured after 30 mins by HTRF-FRET assay relative to control
Format: BAO_0000219
Organism: Homo sapiens
Cell type: CHO
Target: Neurokinin 1 receptor(ALA249)
Document: ALA4190268
Antagonist activity at His6-tagged NK1 receptor (unknown origin) expressed in CHO cells assessed as inhibition of substance-P-induced IP1 accumulation at 10'-5 M preincubated for 10 mins followed by substance-P addition measured after 30 mins by HTRF-FRET assay relative to control: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4192661
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 443.53 | 4.38 | 4.38 |
| 458.50 | 4.28 | 4.28 |
| 413.50 | 4.37 | 4.37 |
| 427.53 | 4.68 | 4.68 |
| 549.50 | 6.41 | 6.41 |
| 458.50 | 4.28 | 4.28 |
| 413.50 | 4.37 | 4.37 |
| 427.53 | 4.68 | 4.68 |
| 489.47 | 3.88 | 3.88 |
| 523.54 | 5.40 | 5.40 |
| 469.57 | 4.86 | 4.86 |
| 443.53 | 4.38 | 4.38 |
| 447.95 | 5.03 | 5.03 |
| 460.47 | 3.64 | 3.64 |
| 413.50 | 4.37 | 4.37 |
| 509.51 | 5.09 | 5.09 |
| 469.57 | 4.86 | 4.86 |
| 458.50 | 4.28 | 4.28 |
| 427.53 | 4.68 | 4.68 |
| 399.48 | 4.07 | 4.07 |
| 447.95 | 5.03 | 5.03 |
| 444.47 | 3.97 | 3.97 |