Basic Information
ID: ALA4195026
Type: Functional
Description: Negative allosteric modulator activity at rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of EC80 glutamate-induced Ca2+ mobilization by Fluo-4 AM dye based fluorescence assay
Organism: Rattus norvegicus
Activity Charts
Bioactivity
Activity Types for Assay ALA4195026
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 325.30 | 2.76 | 2.76 |
| 368.30 | 2.84 | 2.84 |
| 379.42 | 4.10 | 4.10 |
| 375.41 | 3.27 | 3.27 |
| 376.44 | 3.73 | 3.73 |
| 373.39 | 3.96 | 3.96 |
| 402.36 | 3.68 | 3.68 |
| 397.41 | 4.18 | 4.18 |
| 407.38 | 3.82 | 3.82 |
| 391.38 | 4.12 | 4.12 |
| 395.34 | 3.95 | 3.95 |
| 391.38 | 4.12 | 4.12 |
| 369.38 | 3.21 | 3.21 |
| 391.46 | 3.78 | 3.78 |
| 407.38 | 3.82 | 3.82 |
| 375.46 | 4.19 | 4.19 |
| 378.34 | 4.35 | 4.35 |
| 377.35 | 3.87 | 3.87 |
| 373.35 | 3.04 | 3.04 |
| 423.45 | 4.75 | 4.75 |
| 389.39 | 3.55 | 3.55 |
| 391.38 | 4.12 | 4.12 |
| 405.41 | 4.37 | 4.37 |
| 402.36 | 3.68 | 3.68 |
| 373.35 | 3.04 | 3.04 |