Basic Information
ID: ALA4195474
Type: Binding
Description: Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production after 24 hrs by Quanti-blue-based assay
Organism: Homo sapiens
Cell type: HEK293
Activity Charts
Bioactivity
Activity Types for Assay ALA4195474
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 295.75 | 2.18 | 2.18 |
| 358.81 | 2.93 | 2.93 |
| 306.75 | 2.26 | 2.26 |
| 275.70 | 1.81 | 1.81 |
| 329.30 | 2.55 | 2.55 |
| 325.25 | 2.06 | 2.06 |
| 330.20 | 2.83 | 2.83 |
| 344.68 | 2.22 | 2.22 |
| 282.26 | 0.01 | 0.01 |
| 273.25 | -0.16 | -0.16 |
| 324.26 | 1.76 | 1.76 |
| 325.35 | 1.67 | 1.67 |
| 404.15 | 1.91 | 1.91 |
| 262.29 | 0.92 | 0.92 |
| 354.39 | 2.29 | 2.29 |
| 392.36 | 3.30 | 3.30 |
| 358.81 | 2.93 | 2.93 |
| 326.14 | 1.44 | 1.44 |
| 313.74 | 2.90 | 2.90 |
| 341.25 | 1.76 | 1.76 |
| 393.25 | 3.59 | 3.59 |
| 286.32 | 1.40 | 1.40 |
| 325.25 | 1.15 | 1.15 |
| 392.36 | 3.30 | 3.30 |
| 295.75 | 2.18 | 2.18 |
| 403.26 | 3.04 | 3.04 |
| 379.27 | 4.59 | 4.59 |
| 258.24 | -0.47 | -0.47 |
| 309.25 | 2.18 | 2.18 |
| 345.30 | 2.42 | 2.42 |
| 325.25 | 1.88 | 1.88 |
| 293.23 | 0.41 | 0.41 |
| 290.35 | 1.74 | 1.74 |
| 379.34 | 2.83 | 2.83 |
| 325.35 | 1.67 | 1.67 |
| 309.25 | 2.18 | 2.18 |
| 384.42 | 2.30 | 2.30 |
| 352.42 | 2.84 | 2.84 |
| 279.30 | 1.67 | 1.67 |
| 295.75 | 2.18 | 2.18 |
| 281.72 | 1.87 | 1.87 |
| 341.25 | 1.03 | 1.03 |
| 325.25 | 1.15 | 1.15 |
| 319.34 | 1.31 | 1.31 |
| 325.25 | 1.15 | 1.15 |
| 262.29 | 0.92 | 0.92 |
| 384.44 | 1.44 | 1.44 |
| 291.70 | 0.79 | 0.79 |
| 336.15 | 0.90 | 0.90 |
| 324.37 | 2.28 | 2.28 |
| 359.69 | 1.81 | 1.81 |
| 291.69 | 1.52 | 1.52 |
| 393.25 | 3.59 | 3.59 |
| 367.43 | 2.35 | 2.35 |
| 320.15 | 1.92 | 1.92 |
| 277.31 | 1.23 | 1.23 |
| 340.20 | 2.29 | 2.29 |
| 287.28 | 0.14 | 0.14 |
| 310.24 | 1.57 | 1.57 |
| 315.29 | -0.08 | -0.08 |
| 324.26 | 1.76 | 1.76 |
| 291.33 | 1.53 | 1.53 |
| 262.29 | 0.92 | 0.92 |
| 338.39 | 2.59 | 2.59 |
| 342.36 | 2.42 | 2.42 |
| 336.69 | 0.70 | 0.70 |
| 325.25 | 1.88 | 1.88 |
| 342.36 | 2.42 | 2.42 |
| 336.15 | 1.62 | 1.62 |
| 393.25 | 3.59 | 3.59 |
| 295.75 | 2.18 | 2.18 |