Basic Information
ID: ALA4195691
Type: Binding
Description: Inhibition of full-length GST-tagged mouse BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated for 1 hr followed by substrate addition measured after 25 mins by Nu-page gel-based phosphor screen analysis
Format: BAO_0000357
Organism: Mus musculus
Target: Serine/threonine-protein kinase B-raf(ALA2331061)
Document: ALA4190403
Inhibition of full-length GST-tagged mouse BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated for 1 hr followed by substrate addition measured after 25 mins by Nu-page gel-based phosphor screen analysis: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4195691
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 330.39 | 3.77 | 3.77 |
| 346.39 | 3.47 | 3.47 |
| 296.33 | 1.80 | 1.80 |
| 374.40 | 2.78 | 2.78 |
| 344.38 | 2.77 | 2.77 |
| 275.31 | 1.62 | 1.62 |
| 407.86 | 4.04 | 4.04 |
| 316.36 | 3.47 | 3.47 |
| 367.41 | 3.08 | 3.08 |
| 282.31 | 1.32 | 1.32 |
| 455.49 | 4.89 | 4.89 |
| 337.38 | 3.07 | 3.07 |
| 374.40 | 2.78 | 2.78 |
| 351.41 | 3.13 | 3.13 |
| 329.79 | 3.06 | 3.06 |
| 268.32 | 2.50 | 2.50 |
| 391.86 | 4.09 | 4.09 |
| 254.29 | 2.01 | 2.01 |
| 351.41 | 3.38 | 3.38 |
| 289.34 | 2.10 | 2.10 |
| 346.39 | 3.47 | 3.47 |
| 315.76 | 2.58 | 2.58 |
| 358.41 | 2.83 | 2.83 |
| 367.41 | 3.08 | 3.08 |
| 330.39 | 3.52 | 3.52 |