Basic Information
ID: ALA4197292
Type: Binding
Description: Inhibition of calf thymus DNA topoisomerase-1-mediated supercoiled pBR322 DNA relaxation assessed as stabilization of enzyme-DNA complex at 100 uM preincubated with enzyme followed by substrate addition measured after 30 mins by ethidium bromide staining based agarose gel electrophoresis method
Format: BAO_0000357
Organism: Bos taurus
Target: Topoisomerase I(ALA6023)
Document: ALA4196027
Inhibition of calf thymus DNA topoisomerase-1-mediated supercoiled pBR322 DNA relaxation assessed as stabilization of enzyme-DNA complex at 100 uM preincubated with enzyme followed by substrate addition measured after 30 mins by ethidium bromide staining based agarose gel electrophoresis method: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4197292
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 638.58 | 2.23 | 2.23 |
| 654.58 | 1.14 | 1.14 |