Basic Information
ID: ALA4198480
Type: ADME
Description: Inhibition of CYP2C19 in human liver microsomes at 10 uM using mephenytoin as substrate preincubated for 5 mins followed by NADPH addition measured after 20 mins relative to control
Organism: Homo sapiens
Tissue: Liver
Subcellular Fraction: microsomes
Activity Charts
Bioactivity
Activity Types for Assay ALA4198480
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 349.43 | 3.58 | 3.58 |
| 363.46 | 3.89 | 3.89 |
| 369.51 | 3.82 | 3.82 |
| 355.48 | 3.43 | 3.43 |
| 369.51 | 3.67 | 3.67 |
| 363.46 | 3.61 | 3.61 |
| 379.44 | 3.36 | 3.36 |
| 377.49 | 4.00 | 4.00 |
| 375.47 | 3.61 | 3.61 |
| 367.42 | 3.72 | 3.72 |
| 361.45 | 3.22 | 3.22 |
| 375.47 | 3.53 | 3.53 |
| 375.47 | 3.53 | 3.53 |
| 349.43 | 3.30 | 3.30 |
| 389.50 | 4.00 | 4.00 |
| 376.46 | 2.93 | 2.93 |
| 377.49 | 4.36 | 4.36 |
| 391.52 | 4.67 | 4.67 |
| 389.50 | 3.92 | 3.92 |
| 390.49 | 3.32 | 3.32 |