Basic Information
ID: ALA4201751
Type: Binding
Description: Activation of human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli assessed as SOS1-RAS complex formation by measuring exchange of GTP to BODIPY-GDP measured every 3 secs for 30 mins by nucleotide exchange assay relative to control
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4201751
Activity
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 320.44 | 3.11 | 3.11 |
| 281.33 | 3.41 | 3.41 |
| 291.40 | 3.89 | 3.89 |
| 354.89 | 3.76 | 3.76 |
| 346.84 | 3.86 | 3.86 |
| 303.77 | 4.08 | 4.08 |
| 344.82 | 3.29 | 3.29 |
| 386.90 | 4.25 | 4.25 |
| 393.29 | 4.25 | 4.25 |
| 388.44 | 4.13 | 4.13 |
| 338.43 | 3.25 | 3.25 |
| 412.82 | 4.31 | 4.31 |
| 288.75 | 4.49 | 4.49 |
| 358.85 | 3.60 | 3.60 |
| 352.46 | 3.56 | 3.56 |
| 386.90 | 4.29 | 4.29 |
| 372.88 | 3.90 | 3.90 |
| 406.43 | 4.27 | 4.27 |
| 334.47 | 3.42 | 3.42 |
| 423.72 | 4.05 | 4.05 |
| 384.89 | 4.16 | 4.16 |
| 356.42 | 3.39 | 3.39 |
| 386.90 | 4.42 | 4.42 |
| 371.89 | 4.96 | 4.96 |
| 386.90 | 4.66 | 4.66 |
| 366.48 | 3.87 | 3.87 |
| 378.50 | 4.13 | 4.13 |
| 379.27 | 3.94 | 3.94 |