Basic Information
ID: ALA4221468
Type: Binding
Description: Inhibition of sclerostin binding to LRP6 (unknown origin) expressed in rat MC3T3-E1 cells co-expressing TCF/LEF luciferase plasmid assessed as reduction in sclerostin-induced inhibition of Wnt3a activation by measuring luciferase activity at 0.3 uM after 24 hrs by dual-luciferase reporter gene assay (Rvb = 100 +/- 2.6%)
Organism: Homo sapiens
Cell type: MC3T3-E1
Activity Charts
Bioactivity
Activity Types for Assay ALA4221468
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 512.57 | 2.78 | 2.78 |
| 433.49 | 4.13 | 4.13 |
| 501.49 | 5.15 | 5.15 |
| 401.45 | 1.79 | 1.79 |
| 483.55 | 5.29 | 5.29 |