Basic Information
ID: ALA4221489
Type: Binding
Description: Inhibition of recombinant human GlyT1 expressed in CHO cells assessed as reduction in [3H]glycine uptake pretreated for 15 mins followed by [3H]glycine addition measured after 2 hrs by Topcount method
Organism: Homo sapiens
Cell type: CHO
Activity Charts
Bioactivity
Activity Types for Assay ALA4221489
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 410.87 | 5.31 | 5.31 |
| 363.51 | 4.04 | 4.04 |
| 383.92 | 4.27 | 4.27 |
| 381.55 | 4.15 | 4.15 |
| 404.34 | 4.73 | 4.73 |
| 320.44 | 3.53 | 3.53 |
| 442.61 | 5.05 | 5.05 |
| 334.46 | 3.87 | 3.87 |
| 362.52 | 4.79 | 4.79 |
| 374.53 | 4.93 | 4.93 |
| 165.22 | 1.54 | 1.54 |
| 437.89 | 5.10 | 5.10 |
| 466.93 | 5.71 | 5.71 |
| 363.51 | 4.04 | 4.04 |
| 437.89 | 5.10 | 5.10 |
| 480.67 | 4.83 | 4.83 |
| 404.34 | 4.73 | 4.73 |
| 403.35 | 5.34 | 5.34 |
| 348.49 | 4.26 | 4.26 |
| 414.35 | 4.19 | 4.19 |
| 404.34 | 4.73 | 4.73 |
| 348.49 | 4.31 | 4.31 |
| 335.45 | 3.45 | 3.45 |
| 403.35 | 5.34 | 5.34 |
| 450.93 | 6.01 | 6.01 |
| 437.89 | 5.10 | 5.10 |
| 366.51 | 4.55 | 4.55 |
| 515.80 | 6.47 | 6.47 |
| 421.44 | 4.59 | 4.59 |
| 466.93 | 5.71 | 5.71 |
| 334.46 | 4.06 | 4.06 |
| 426.87 | 5.30 | 5.30 |
| 450.93 | 6.01 | 6.01 |
| 394.52 | 4.05 | 4.05 |
| 416.92 | 5.52 | 5.52 |
| 466.93 | 5.71 | 5.71 |
| 436.90 | 5.70 | 5.70 |
| 348.49 | 4.40 | 4.40 |
| 362.52 | 4.65 | 4.65 |
| 376.54 | 5.18 | 5.18 |
| 436.90 | 5.70 | 5.70 |
| 377.53 | 4.57 | 4.57 |
| 436.90 | 5.70 | 5.70 |
| 450.93 | 6.01 | 6.01 |
| 399.92 | 4.09 | 4.09 |