Basic Information
ID: ALA4222778
Type: Binding
Description: Inverse agonist activity at RORgamma (unknown origin) expressed in human HeLa-derived HG5LN cells transfected with the GAL4 DNA-binding domain fused to the ROR gamma ligand-binding domain assessed as inhibition of transcriptional activity after 18 hrs by luminescence-based luciferase reporter gene assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4222778
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 493.69 | 4.64 | 4.64 |
| 522.73 | 5.33 | 5.33 |
| 521.75 | 5.36 | 5.36 |
| 461.62 | 4.40 | 4.40 |
| 525.71 | 5.07 | 5.07 |
| 571.79 | 3.94 | 3.94 |
| 508.71 | 4.94 | 4.94 |
| 431.60 | 4.91 | 4.91 |
| 520.72 | 3.80 | 3.80 |
| 523.72 | 4.09 | 4.09 |
| 508.71 | 4.94 | 4.94 |
| 522.73 | 4.99 | 4.99 |
| 535.78 | 5.75 | 5.75 |
| 535.73 | 4.53 | 4.53 |
| 507.72 | 4.01 | 4.01 |
| 507.72 | 4.97 | 4.97 |
| 489.63 | 4.53 | 4.53 |
| 521.75 | 5.36 | 5.36 |
| 494.68 | 4.69 | 4.69 |
| 509.69 | 4.31 | 4.31 |
| 488.65 | 3.93 | 3.93 |
| 508.71 | 4.94 | 4.94 |
| 510.68 | 3.55 | 3.55 |
| 521.75 | 5.00 | 5.00 |
| 470.64 | 4.97 | 4.97 |
| 521.75 | 5.36 | 5.36 |