Basic Information
ID: ALA4222975
Type: Binding
Description: Inhibition of mouse full length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated for 1 hr followed by substrate addition measured after 25 mins by Nu-page gel-based phosphor screen analysis
Format: BAO_0000357
Organism: Mus musculus
Target: Serine/threonine-protein kinase B-raf(ALA2331061)
Document: ALA4219184
Inhibition of mouse full length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated for 1 hr followed by substrate addition measured after 25 mins by Nu-page gel-based phosphor screen analysis: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4222975
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 464.83 | 5.55 | 5.55 |
| 391.82 | 4.12 | 4.12 |
| 355.40 | 4.67 | 4.67 |
| 389.84 | 5.33 | 5.33 |
| 357.37 | 3.46 | 3.46 |
| 391.82 | 4.12 | 4.12 |
| 436.27 | 4.23 | 4.23 |
| 405.84 | 5.68 | 5.68 |
| 448.48 | 5.86 | 5.86 |
| 371.40 | 3.77 | 3.77 |
| 356.39 | 4.07 | 4.07 |
| 412.49 | 5.37 | 5.37 |
| 390.83 | 4.72 | 4.72 |
| 390.83 | 4.72 | 4.72 |
| 356.39 | 4.07 | 4.07 |
| 435.28 | 4.83 | 4.83 |
| 390.83 | 4.72 | 4.72 |
| 447.49 | 6.46 | 6.46 |
| 424.38 | 5.09 | 5.09 |
| 374.38 | 4.21 | 4.21 |
| 374.38 | 4.21 | 4.21 |