Basic Information
ID: ALA4224046
Type: ADME
Description: Inhibition of human recombinant DHFR expressed in Escherichia coli Rosetta Gami B (DE3) competent cells using DHFA as substrate and NADPH
Format: BAO_0000219
Organism: Homo sapiens
Target: Dihydrofolate reductase(ALA202)
Document: ALA4219246
Inhibition of human recombinant DHFR expressed in Escherichia coli Rosetta Gami B (DE3) competent cells using DHFA as substrate and NADPH: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4224046
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 290.32 | 1.26 | 1.26 |
| 325.37 | 2.11 | 2.11 |
| 321.41 | 3.74 | 3.74 |
| 301.38 | 2.59 | 2.59 |
| 301.38 | 2.59 | 2.59 |
| 301.38 | 2.59 | 2.59 |
| 321.41 | 3.74 | 3.74 |
| 321.36 | 2.87 | 2.87 |
| 369.37 | 3.49 | 3.49 |
| 355.35 | 3.48 | 3.48 |
| 315.40 | 2.60 | 2.60 |
| 307.33 | 2.86 | 2.86 |
| 315.40 | 2.60 | 2.60 |
| 329.43 | 3.08 | 3.08 |
| 335.44 | 3.75 | 3.75 |
| 343.46 | 3.64 | 3.64 |
| 315.40 | 2.60 | 2.60 |
| 343.46 | 3.47 | 3.47 |
| 357.48 | 3.86 | 3.86 |
| 335.44 | 3.75 | 3.75 |