Basic Information
ID: ALA4231621
Type: Binding
Description: Inhibition of mPGES1 in IL-1beta-stimulated human A549 cell microsomal fractions assessed as reduction in PGE2 production at 3 uM preincubated for 15 mins followed by PGH2 substrate addition and measured after 1 min by RP-HPLC analysis relative to control
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4231621
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 427.98 | 6.96 | 6.96 |
| 505.06 | 7.33 | 7.33 |
| 446.98 | 6.79 | 6.79 |
| 464.96 | 5.43 | 5.43 |
| 478.99 | 6.00 | 6.00 |
| 523.08 | 8.45 | 8.45 |
| 487.00 | 6.43 | 6.43 |
| 477.00 | 6.55 | 6.55 |
| 461.01 | 6.72 | 6.72 |
| 523.08 | 8.45 | 8.45 |
| 475.03 | 7.11 | 7.11 |
| 471.00 | 7.14 | 7.14 |
| 482.05 | 5.74 | 5.74 |
| 461.01 | 6.72 | 6.72 |
| 471.01 | 6.27 | 6.27 |
| 523.08 | 8.45 | 8.45 |
| 475.03 | 7.11 | 7.11 |
| 530.09 | 7.91 | 7.91 |
| 503.07 | 7.80 | 7.80 |