Assay Report Card

Basic Information

ID: ALA4233174

Type: Binding

Description: Selectivity ratio of IC50 for inhibition of SOAT2 in New Zealand white rabbit intestinal microsomes to IC50 for inhibition of SOAT1 in arterial homogenates isolated from 1% cholesterol fed New Zealand white rabbit

Organism: Oryctolagus cuniculus

Strain: New Zealand white

Activity Charts

Bioactivity

Activity Types for Assay ALA4233174

Ratio IC50

Total(63)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
590.78	9.79	9.79
393.57	6.21	6.21
501.73	7.29	7.29
468.62	7.06	7.06
425.60	6.76	6.76
398.60	6.66	6.66
423.63	7.10	7.10
440.61	7.07	7.07
440.68	7.83	7.83
467.68	7.43	7.43
481.71	7.43	7.43
482.65	7.15	7.15
424.61	7.37	7.37
367.52	5.54	5.54
410.58	6.98	6.98
440.61	7.07	7.07
482.76	9.00	9.00
454.64	6.86	6.86
549.87	10.61	10.61
451.68	7.88	7.88
412.62	7.05	7.05
409.60	6.71	6.71
467.68	7.43	7.43
481.71	7.43	7.43
482.65	7.15	7.15
467.68	7.43	7.43
452.66	8.15	8.15
468.62	7.06	7.06
382.53	6.20	6.20
454.71	8.22	8.22
440.61	7.07	7.07
479.73	8.66	8.66
468.62	7.06	7.06
481.71	7.43	7.43
496.79	9.39	9.39
440.61	7.07	7.07
454.64	6.86	6.86
550.85	10.88	10.88
482.65	7.15	7.15
566.92	11.35	11.35
384.57	6.27	6.27
437.65	7.49	7.49
425.60	6.76	6.76
368.50	5.81	5.81
466.69	8.54	8.54
438.64	7.76	7.76
426.65	7.44	7.44
468.73	8.61	8.61
465.71	8.27	8.27
425.60	6.76	6.76
492.61	8.38	8.38
467.68	7.43	7.43
454.64	6.86	6.86
454.64	6.86	6.86
395.57	6.32	6.32
432.59	5.54	5.54
468.62	7.06	7.06
438.64	7.67	7.67
396.56	6.59	6.59
480.72	8.93	8.93
481.71	7.43	7.43
482.65	7.15	7.15
425.60	6.76	6.76