Basic Information
ID: ALA4233470
Type: Functional
Description: Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux preincubated for 2.5 mins followed by glutamate addition by Fluo-4-AM dye based fluorescence assay
Organism: Homo sapiens
Cell type: CHO
Activity Charts
Bioactivity
Activity Types for Assay ALA4233470
EC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 232.67 | 2.99 | 2.99 |
| 262.68 | 3.49 | 3.49 |
| 379.40 | 2.77 | 2.77 |
| 318.38 | 3.64 | 3.64 |
| 265.28 | 1.98 | 1.98 |
| 292.35 | 3.15 | 3.15 |
| 336.40 | 3.62 | 3.62 |
| 264.29 | 2.59 | 2.59 |
| 304.36 | 3.47 | 3.47 |
| 312.76 | 3.72 | 3.72 |
| 379.40 | 2.82 | 2.82 |
| 397.39 | 3.12 | 3.12 |
| 397.39 | 3.07 | 3.07 |
| 321.40 | 3.95 | 3.95 |
| 304.36 | 3.47 | 3.47 |
| 332.41 | 4.16 | 4.16 |
| 321.40 | 3.95 | 3.95 |
| 290.33 | 3.46 | 3.46 |
| 306.37 | 3.94 | 3.94 |
| 292.35 | 3.38 | 3.38 |
| 375.39 | 3.46 | 3.46 |
| 263.30 | 3.19 | 3.19 |
| 264.29 | 2.59 | 2.59 |
| 372.35 | 4.49 | 4.49 |
| 332.41 | 4.47 | 4.47 |
| 377.45 | 3.06 | 3.06 |
| 346.32 | 3.69 | 3.69 |
| 305.35 | 2.86 | 2.86 |
| 318.38 | 3.95 | 3.95 |
| 322.37 | 3.38 | 3.38 |
| 265.28 | 2.05 | 2.05 |
| 332.29 | 3.61 | 3.61 |
| 332.41 | 4.16 | 4.16 |
| 319.37 | 3.03 | 3.03 |
| 379.40 | 2.77 | 2.77 |
| 265.28 | 2.05 | 2.05 |
| 305.35 | 2.86 | 2.86 |
| 364.41 | 3.15 | 3.15 |
| 411.42 | 3.46 | 3.46 |
| 361.41 | 2.82 | 2.82 |
| 378.44 | 3.54 | 3.54 |
| 361.41 | 2.87 | 2.87 |
| 332.41 | 4.47 | 4.47 |
| 278.32 | 2.90 | 2.90 |
| 278.32 | 2.90 | 2.90 |
| 264.29 | 2.59 | 2.59 |
| 318.38 | 3.64 | 3.64 |