Basic Information
ID: ALA4234830
Type: Binding
Description: Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake at 200 uM preincubated for 3 mins at 37 degC followed by washing with choline buffer and measured after 3 hrs by scintillation counting analysis relative to BCH
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4234830
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 146.19 | -0.47 | -0.47 |
| 133.10 | -1.13 | -1.13 |
| 155.16 | -0.64 | -0.64 |
| 75.07 | -0.97 | -0.97 |
| 117.15 | 0.05 | 0.05 |
| 181.19 | 0.35 | 0.35 |
| 165.19 | 0.64 | 0.64 |
| 131.17 | 0.44 | 0.44 |
| 204.23 | 1.12 | 1.12 |
| 241.29 | 2.31 | 2.31 |
| 204.23 | 1.12 | 1.12 |
| 155.16 | -0.64 | -0.64 |
| 171.24 | 1.37 | 1.37 |
| 171.24 | 1.37 | 1.37 |
| 165.19 | 0.64 | 0.64 |
| 174.20 | -1.34 | -1.34 |
| 147.13 | -0.74 | -0.74 |
| 181.19 | 0.35 | 0.35 |
| 190.20 | 0.51 | 0.51 |
| 179.22 | 0.95 | 0.95 |
| 179.22 | 0.95 | 0.95 |
| 131.18 | 0.44 | 0.44 |
| 117.15 | 0.05 | 0.05 |
| 181.19 | 0.35 | 0.35 |
| 169.18 | -0.63 | -0.63 |
| 149.22 | 0.15 | 0.15 |
| 221.30 | 1.94 | 1.94 |
| 255.32 | 2.23 | 2.23 |
| 223.23 | 0.57 | 0.57 |
| 209.20 | 0.34 | 0.34 |
| 221.30 | 2.06 | 2.06 |
| 207.23 | 0.84 | 0.84 |
| 131.18 | 0.44 | 0.44 |
| 245.28 | 0.89 | 0.89 |
| 222.24 | 0.00 | 0.00 |
| 237.25 | 0.74 | 0.74 |
| 209.20 | 0.34 | 0.34 |
| 245.28 | 0.98 | 0.98 |
| 223.23 | 0.43 | 0.43 |
| 223.23 | 0.27 | 0.27 |
| 221.30 | 2.06 | 2.06 |
| 166.18 | 0.04 | 0.04 |
| 237.25 | 0.36 | 0.36 |
| 166.18 | 0.04 | 0.04 |
| 194.23 | 0.10 | 0.10 |
| 253.25 | -0.21 | -0.21 |
| 223.23 | 0.43 | 0.43 |
| 239.34 | 1.76 | 1.76 |
| 223.23 | 0.43 | 0.43 |
| 180.21 | 0.22 | 0.22 |
| 255.32 | 2.25 | 2.25 |
| 239.34 | 1.76 | 1.76 |
| 233.19 | 1.66 | 1.66 |
| 209.20 | 0.34 | 0.34 |
| 222.24 | 0.60 | 0.60 |
| 265.31 | 1.60 | 1.60 |
| 223.23 | 0.65 | 0.65 |
| 166.18 | 0.04 | 0.04 |
| 195.22 | 0.13 | 0.13 |