Assay Report Card

Basic Information

ID: ALA4251999

Type: Binding

Description: Positive allosteric modulation of human GlyRalpha3beta expressed in HEK293T cells assessed as increase in glycine-induced chloride ion flux measured for 4 mins by FLIPR assay

Organism: Homo sapiens

Activity Charts

Bioactivity

Activity Types for Assay ALA4251999

EC50

Total(197)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
386.43	1.80	1.80
490.49	4.08	4.08
332.38	2.34	2.34
338.39	0.51	0.51
374.46	2.84	2.84
393.85	2.68	2.68
418.47	2.46	2.46
332.38	2.34	2.34
319.34	2.00	2.00
395.46	1.65	1.65
361.42	2.40	2.40
411.48	3.32	3.32
363.39	1.88	1.88
334.40	2.06	2.06
428.51	2.62	2.62
378.43	2.06	2.06
411.86	2.92	2.92
377.42	2.27	2.27
397.46	2.47	2.47
377.47	2.41	2.41
366.44	1.58	1.58
377.42	2.01	2.01
427.49	1.57	1.57
381.84	2.35	2.35
397.45	-0.42	-0.42
317.37	2.16	2.16
400.46	2.16	2.16
319.38	2.28	2.28
361.42	2.65	2.65
388.45	1.49	1.49
377.42	2.12	2.12
381.38	2.01	2.01
376.43	1.93	1.93
363.39	1.88	1.88
411.86	2.92	2.92
357.39	2.01	2.01
358.38	1.47	1.47
428.51	2.89	2.89
350.40	1.11	1.11
373.43	2.63	2.63
384.41	1.86	1.86
372.41	1.49	1.49
338.39	0.51	0.51
366.48	2.30	2.30
397.50	0.44	0.44
374.42	1.69	1.69
352.46	2.05	2.05
407.88	2.69	2.69
315.35	0.45	0.45
389.43	2.71	2.71
361.42	1.32	1.32
366.48	2.44	2.44
377.42	2.18	2.18
354.43	0.90	0.90
365.38	2.25	2.25
377.42	2.27	2.27
397.84	2.53	2.53
370.43	3.07	3.07
350.40	1.11	1.11
346.41	1.53	1.53
411.48	3.23	3.23
357.39	2.01	2.01
348.38	1.40	1.40
361.42	2.05	2.05
413.46	3.03	3.03
346.41	2.38	2.38
411.48	3.30	3.30
320.37	1.67	1.67
350.37	2.04	2.04
332.38	1.90	1.90
450.43	3.20	3.20
361.42	2.60	2.60
346.41	2.21	2.21
350.37	2.04	2.04
368.41	2.75	2.75
373.39	0.88	0.88
348.42	2.45	2.45
300.38	0.99	0.99
404.44	2.22	2.22
337.32	2.38	2.38
410.84	2.23	2.23
375.45	2.79	2.79
337.36	1.28	1.28
347.40	1.32	1.32
373.43	2.57	2.57
348.38	1.65	1.65
391.45	2.66	2.66
361.42	2.29	2.29
342.42	0.76	0.76
352.46	1.91	1.91
381.38	2.01	2.01
358.42	1.85	1.85
398.44	2.81	2.81
354.43	0.90	0.90
361.42	2.50	2.50
391.45	2.66	2.66
404.49	2.11	2.11
412.51	1.31	1.31
372.45	2.24	2.24
338.39	0.51	0.51
371.42	2.32	2.32
346.41	1.93	1.93
338.43	1.52	1.52
386.43	3.12	3.12
361.42	2.01	2.01
386.43	2.52	2.52
361.42	2.09	2.09
303.34	2.17	2.17
331.39	2.59	2.59
356.40	2.27	2.27
365.38	2.40	2.40
271.29	0.43	0.43
411.86	2.92	2.92
348.38	1.65	1.65
347.39	2.26	2.26
361.42	2.35	2.35
266.28	0.56	0.56
320.37	1.67	1.67
315.35	0.45	0.45
352.46	2.05	2.05
386.43	2.19	2.19
377.42	1.88	1.88
378.43	2.06	2.06
363.39	1.88	1.88
398.44	1.87	1.87
366.48	2.30	2.30
381.38	2.01	2.01
414.48	2.62	2.62
307.33	0.86	0.86
349.38	2.73	2.73
410.90	3.41	3.41
378.43	2.06	2.06
362.41	1.91	1.91
255.29	1.20	1.20
386.43	2.52	2.52
431.51	2.94	2.94
375.45	2.40	2.40
382.83	2.31	2.31
347.39	2.18	2.18
373.45	1.00	1.00
257.27	-0.22	-0.22
350.37	2.04	2.04
407.88	2.69	2.69
360.44	1.97	1.97
386.43	3.12	3.12
411.86	2.92	2.92
323.37	0.64	0.64
332.38	2.34	2.34
333.37	1.87	1.87
366.44	1.44	1.44
349.41	1.71	1.71
426.49	2.83	2.83
381.50	1.21	1.21
340.45	1.91	1.91
381.38	2.01	2.01
377.42	2.01	2.01
380.47	1.83	1.83
334.40	2.37	2.37
349.38	2.73	2.73
399.47	3.17	3.17
349.38	2.73	2.73
346.41	2.73	2.73
365.38	2.40	2.40
426.50	2.87	2.87
375.45	2.17	2.17
403.44	3.00	3.00
388.45	2.09	2.09
396.47	3.24	3.24
375.45	2.99	2.99
393.85	2.68	2.68