Basic Information
ID: ALA4256223
Type: Binding
Description: Inhibition of ATR in human U2OS cells harboring ER-LBD fused TopBPI activation domain (978 to 1286 residues) assessed as reduction in 4-OHT-mediated nuclear translocation of TopBPI fragment by measuring gammaH2AX level after 24 hrs by Alexa Fluor 488 staining based fluorescence assay
Organism: Homo sapiens
Cell type: U2OS
Activity Charts
Bioactivity
Activity Types for Assay ALA4256223
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 472.57 | 2.12 | 2.12 |
| 472.57 | 2.33 | 2.33 |
| 422.51 | 0.97 | 0.97 |
| 410.48 | 2.28 | 2.28 |