Basic Information
ID: ALA4257014
Type: Binding
Description: Inhibition of IDH2 R140Q mutant homodimer (unknown origin) expressed in Sf9 cells pre-incubated for 1 hr before addition of alpha-KG followed by 16 hrs incubation in presence of NADPH, NADP, diaphorase and resazurin by fluorescence spectrometry based cofactor depletion assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4257014
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 343.48 | 3.43 | 3.43 |
| 459.88 | 4.96 | 4.96 |
| 448.36 | 4.17 | 4.17 |
| 487.38 | 5.36 | 5.36 |
| 415.73 | 3.71 | 3.71 |
| 480.38 | 4.62 | 4.62 |
| 436.34 | 4.09 | 4.09 |
| 506.36 | 5.10 | 5.10 |
| 441.36 | 3.55 | 3.55 |
| 490.44 | 5.10 | 5.10 |
| 419.33 | 3.69 | 3.69 |
| 491.35 | 5.32 | 5.32 |
| 464.39 | 5.15 | 5.15 |
| 501.41 | 5.80 | 5.80 |
| 444.46 | 4.65 | 4.65 |
| 484.46 | 4.95 | 4.95 |
| 470.42 | 5.21 | 5.21 |
| 391.40 | 3.88 | 3.88 |
| 466.46 | 5.31 | 5.31 |
| 437.27 | 3.80 | 3.80 |
| 464.39 | 5.15 | 5.15 |
| 483.38 | 4.13 | 4.13 |
| 493.42 | 5.70 | 5.70 |
| 478.43 | 5.16 | 5.16 |
| 476.35 | 5.46 | 5.46 |
| 424.37 | 4.35 | 4.35 |
| 392.43 | 4.37 | 4.37 |
| 414.74 | 4.31 | 4.31 |
| 494.35 | 4.83 | 4.83 |
| 454.34 | 4.04 | 4.04 |
| 414.74 | 4.31 | 4.31 |
| 454.32 | 4.74 | 4.74 |
| 462.39 | 4.56 | 4.56 |
| 464.39 | 5.15 | 5.15 |
| 468.37 | 4.82 | 4.82 |
| 315.43 | 2.65 | 2.65 |
| 421.81 | 4.57 | 4.57 |
| 505.37 | 5.71 | 5.71 |
| 410.95 | 4.79 | 4.79 |
| 503.44 | 4.64 | 4.64 |
| 483.38 | 4.13 | 4.13 |
| 431.83 | 4.18 | 4.18 |
| 430.84 | 4.79 | 4.79 |
| 465.38 | 4.55 | 4.55 |
| 477.33 | 4.85 | 4.85 |
| 420.36 | 4.53 | 4.53 |
| 506.36 | 5.10 | 5.10 |
| 515.44 | 6.19 | 6.19 |
| 510.90 | 5.78 | 5.78 |
| 430.39 | 3.15 | 3.15 |
| 414.44 | 4.77 | 4.77 |
| 511.40 | 5.77 | 5.77 |
| 396.42 | 3.61 | 3.61 |
| 520.39 | 5.49 | 5.49 |
| 508.47 | 6.05 | 6.05 |
| 465.38 | 4.55 | 4.55 |
| 396.42 | 3.35 | 3.35 |
| 497.33 | 5.47 | 5.47 |
| 503.44 | 4.64 | 4.64 |
| 436.34 | 4.37 | 4.37 |
| 505.37 | 5.71 | 5.71 |
| 504.45 | 5.93 | 5.93 |
| 494.40 | 5.01 | 5.01 |
| 343.48 | 3.43 | 3.43 |
| 432.39 | 4.31 | 4.31 |
| 502.45 | 5.25 | 5.25 |
| 476.41 | 4.95 | 4.95 |
| 471.82 | 5.34 | 5.34 |
| 470.46 | 3.83 | 3.83 |
| 446.42 | 4.13 | 4.13 |
| 505.43 | 6.12 | 6.12 |
| 447.40 | 3.89 | 3.89 |
| 419.33 | 3.69 | 3.69 |
| 339.44 | 3.67 | 3.67 |
| 483.38 | 4.13 | 4.13 |
| 464.39 | 5.15 | 5.15 |
| 454.32 | 4.74 | 4.74 |
| 489.47 | 5.42 | 5.42 |
| 464.50 | 6.30 | 6.30 |
| 494.44 | 5.27 | 5.27 |
| 495.39 | 4.40 | 4.40 |
| 430.84 | 4.79 | 4.79 |
| 489.41 | 4.25 | 4.25 |
| 480.48 | 5.91 | 5.91 |
| 382.39 | 2.96 | 2.96 |
| 507.47 | 4.03 | 4.03 |
| 490.44 | 5.10 | 5.10 |
| 452.43 | 5.13 | 5.13 |
| 487.38 | 5.41 | 5.41 |
| 449.28 | 4.07 | 4.07 |
| 505.37 | 5.71 | 5.71 |
| 440.35 | 4.83 | 4.83 |
| 454.41 | 4.81 | 4.81 |
| 503.44 | 4.64 | 4.64 |
| 486.30 | 4.60 | 4.60 |
| 403.77 | 3.40 | 3.40 |
| 386.93 | 4.79 | 4.79 |
| 428.46 | 5.34 | 5.34 |
| 413.41 | 4.78 | 4.78 |
| 461.40 | 4.99 | 4.99 |
| 498.47 | 5.99 | 5.99 |
| 418.35 | 4.29 | 4.29 |
| 491.35 | 5.18 | 5.18 |
| 449.28 | 4.07 | 4.07 |
| 477.33 | 4.85 | 4.85 |
| 414.74 | 4.31 | 4.31 |
| 494.51 | 6.09 | 6.09 |
| 501.41 | 5.80 | 5.80 |
| 439.80 | 4.60 | 4.60 |
| 440.38 | 4.42 | 4.42 |
| 504.51 | 6.30 | 6.30 |
| 453.37 | 4.28 | 4.28 |
| 477.40 | 3.98 | 3.98 |
| 456.35 | 4.33 | 4.33 |
| 442.80 | 5.09 | 5.09 |
| 414.40 | 4.17 | 4.17 |
| 527.50 | 6.75 | 6.75 |
| 368.41 | 4.37 | 4.37 |
| 447.87 | 4.69 | 4.69 |
| 454.38 | 5.22 | 5.22 |
| 513.47 | 6.36 | 6.36 |
| 393.42 | 3.77 | 3.77 |
| 451.36 | 3.69 | 3.69 |
| 529.48 | 5.03 | 5.03 |
| 443.32 | 3.45 | 3.45 |
| 505.46 | 4.76 | 4.76 |
| 503.44 | 4.64 | 4.64 |
| 437.28 | 3.09 | 3.09 |
| 465.38 | 4.55 | 4.55 |
| 471.39 | 4.98 | 4.98 |
| 442.80 | 5.09 | 5.09 |
| 493.43 | 5.33 | 5.33 |
| 494.40 | 5.01 | 5.01 |
| 508.47 | 6.05 | 6.05 |
| 461.35 | 4.70 | 4.70 |
| 468.90 | 4.88 | 4.88 |
| 392.43 | 4.38 | 4.38 |
| 428.46 | 5.34 | 5.34 |
| 506.36 | 5.10 | 5.10 |
| 498.49 | 5.34 | 5.34 |
| 449.77 | 3.70 | 3.70 |
| 438.40 | 4.53 | 4.53 |
| 473.36 | 4.97 | 4.97 |
| 426.32 | 4.44 | 4.44 |
| 465.38 | 4.55 | 4.55 |
| 478.40 | 5.64 | 5.64 |
| 465.38 | 4.55 | 4.55 |
| 480.39 | 5.03 | 5.03 |
| 528.49 | 5.64 | 5.64 |
| 453.30 | 4.46 | 4.46 |
| 442.36 | 4.43 | 4.43 |
| 374.44 | 4.29 | 4.29 |
| 531.41 | 6.10 | 6.10 |
| 465.38 | 4.55 | 4.55 |
| 447.32 | 4.31 | 4.31 |
| 493.43 | 5.33 | 5.33 |
| 512.52 | 5.73 | 5.73 |
| 473.36 | 4.97 | 4.97 |
| 505.37 | 5.71 | 5.71 |
| 488.42 | 4.71 | 4.71 |
| 443.43 | 3.98 | 3.98 |
| 486.42 | 5.13 | 5.13 |
| 437.32 | 3.77 | 3.77 |
| 418.47 | 4.76 | 4.76 |
| 446.82 | 4.25 | 4.25 |
| 458.89 | 5.57 | 5.57 |
| 491.43 | 4.37 | 4.37 |
| 486.30 | 4.60 | 4.60 |
| 505.43 | 6.12 | 6.12 |
| 452.33 | 4.25 | 4.25 |
| 465.32 | 4.58 | 4.58 |
| 476.45 | 5.13 | 5.13 |
| 465.36 | 4.92 | 4.92 |
| 506.48 | 4.64 | 4.64 |
| 481.42 | 5.06 | 5.06 |
| 371.46 | 4.11 | 4.11 |
| 539.87 | 6.77 | 6.77 |
| 432.92 | 4.49 | 4.49 |
| 464.40 | 4.92 | 4.92 |
| 425.78 | 4.21 | 4.21 |
| 488.48 | 6.02 | 6.02 |
| 358.88 | 4.01 | 4.01 |
| 502.45 | 5.25 | 5.25 |
| 492.33 | 4.71 | 4.71 |
| 505.37 | 5.57 | 5.57 |
| 530.44 | 5.99 | 5.99 |
| 437.34 | 3.30 | 3.30 |
| 486.40 | 5.96 | 5.96 |
| 364.38 | 3.88 | 3.88 |
| 474.45 | 5.85 | 5.85 |
| 488.42 | 4.86 | 4.86 |
| 457.45 | 4.63 | 4.63 |
| 460.32 | 4.19 | 4.19 |
| 461.41 | 4.64 | 4.64 |
| 444.34 | 4.06 | 4.06 |
| 480.32 | 4.44 | 4.44 |
| 478.43 | 5.31 | 5.31 |
| 451.40 | 4.67 | 4.67 |
| 552.55 | 6.95 | 6.95 |
| 447.39 | 4.47 | 4.47 |
| 414.74 | 4.31 | 4.31 |
| 460.43 | 5.24 | 5.24 |
| 425.31 | 3.50 | 3.50 |
| 440.47 | 5.26 | 5.26 |
| 519.40 | 6.10 | 6.10 |
| 451.36 | 3.69 | 3.69 |
| 472.37 | 5.57 | 5.57 |
| 491.43 | 4.37 | 4.37 |
| 364.38 | 3.60 | 3.60 |
| 443.42 | 3.67 | 3.67 |
| 442.36 | 4.43 | 4.43 |
| 442.80 | 5.09 | 5.09 |
| 353.47 | 3.45 | 3.45 |
| 523.42 | 6.26 | 6.26 |
| 483.30 | 5.08 | 5.08 |
| 494.40 | 5.01 | 5.01 |
| 497.38 | 5.38 | 5.38 |
| 490.43 | 5.54 | 5.54 |
| 339.45 | 2.94 | 2.94 |
| 532.40 | 5.49 | 5.49 |
| 479.39 | 5.31 | 5.31 |
| 475.44 | 5.25 | 5.25 |
| 468.71 | 4.85 | 4.85 |
| 478.42 | 5.54 | 5.54 |
| 437.32 | 3.77 | 3.77 |
| 442.80 | 5.09 | 5.09 |
| 468.37 | 4.43 | 4.43 |
| 450.38 | 4.53 | 4.53 |
| 381.41 | 3.50 | 3.50 |
| 432.37 | 4.46 | 4.46 |
| 429.38 | 4.53 | 4.53 |
| 439.31 | 3.08 | 3.08 |
| 491.43 | 4.37 | 4.37 |
| 386.84 | 1.70 | 1.70 |
| 433.36 | 3.86 | 3.86 |
| 502.45 | 5.25 | 5.25 |
| 486.30 | 4.60 | 4.60 |
| 494.51 | 6.09 | 6.09 |
| 493.43 | 5.33 | 5.33 |
| 501.41 | 5.80 | 5.80 |
| 517.47 | 5.03 | 5.03 |
| 475.44 | 5.25 | 5.25 |
| 464.39 | 5.15 | 5.15 |
| 503.44 | 4.64 | 4.64 |
| 438.84 | 4.53 | 4.53 |
| 485.42 | 5.37 | 5.37 |
| 506.36 | 5.10 | 5.10 |
| 516.48 | 5.64 | 5.64 |
| 503.44 | 4.64 | 4.64 |
| 464.39 | 4.87 | 4.87 |
| 437.38 | 4.28 | 4.28 |
| 437.32 | 3.77 | 3.77 |
| 498.47 | 5.99 | 5.99 |
| 372.35 | 1.54 | 1.54 |
| 494.35 | 4.83 | 4.83 |
| 503.44 | 4.64 | 4.64 |