Basic Information
ID: ALA4257015
Type: Binding
Description: Inhibition of IDH2 R140Q mutant homodimer (unknown origin) expressed in Sf9 cells pre-incubated for 6 hrs before addition of alpha-KG followed by 60 mins incubation in presence of NADPH, NADP, diaphorase and resazurin by fluorescence spectrometry based cofactor depletion assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4257015
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 441.36 | 3.55 | 3.55 |
| 444.46 | 4.65 | 4.65 |
| 557.57 | 5.75 | 5.75 |
| 458.53 | 5.40 | 5.40 |
| 478.43 | 5.16 | 5.16 |
| 405.43 | 4.12 | 4.12 |
| 430.84 | 4.79 | 4.79 |
| 420.36 | 4.53 | 4.53 |
| 432.39 | 4.31 | 4.31 |
| 447.40 | 3.89 | 3.89 |
| 391.44 | 4.98 | 4.98 |
| 454.41 | 4.81 | 4.81 |
| 386.93 | 4.79 | 4.79 |
| 413.41 | 4.78 | 4.78 |
| 533.51 | 4.88 | 4.88 |
| 535.54 | 3.78 | 3.78 |
| 440.38 | 4.42 | 4.42 |
| 482.91 | 5.57 | 5.57 |
| 393.42 | 3.77 | 3.77 |
| 424.47 | 4.39 | 4.39 |
| 391.44 | 4.98 | 4.98 |
| 468.90 | 4.88 | 4.88 |
| 356.82 | 3.02 | 3.02 |
| 505.37 | 5.71 | 5.71 |
| 418.47 | 4.76 | 4.76 |
| 432.92 | 4.49 | 4.49 |
| 464.40 | 4.92 | 4.92 |
| 435.83 | 5.54 | 5.54 |
| 499.49 | 4.37 | 4.37 |
| 458.44 | 4.53 | 4.53 |
| 438.84 | 4.53 | 4.53 |
| 519.52 | 5.24 | 5.24 |