Basic Information
ID: ALA4257111
Type: Functional
Description: In vivo inhibition of NHE3 in Sprague-Dawley rat assessed as inhibition of sodium absorption from intestinal lumen by measuring urinary sodium concentration at 10 mg/kg, po via gavage measured after 16 hrs relative to control
Organism: Rattus norvegicus
Strain: Sprague-Dawley
Activity Charts
Bioactivity
Activity Types for Assay ALA4257111
Activity
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 1145.07 | ||
| 371.29 | 3.22 | 3.22 |
| 1205.12 | ||
| 1888.82 | ||
| 1868.87 | ||
| 1263.54 | ||
| 513.05 | 1.97 | 1.97 |
| 1848.72 | ||
| 1088.19 | ||
| 1314.39 | ||
| 2318.15 | ||
| 1582.57 | ||
| 1777.63 | ||
| 1252.34 | ||
| 503.67 | 2.49 | 2.49 |
| 1466.49 | ||
| 1225.54 | ||
| 1437.45 | ||
| 1137.43 | ||
| 1485.59 | ||
| 1136.23 | ||
| 1582.57 | ||
| 1437.45 | ||
| 747.18 | 7.01 | 7.01 |
| 714.80 | 6.55 | 6.55 |
| 1776.64 | ||
| 764.86 | 7.43 | 7.43 |
| 1644.49 | ||
| 1309.39 | ||
| 1773.69 | ||
| 1104.19 | ||
| 1504.63 | ||
| 1901.26 | ||
| 508.00 | 1.53 | 1.53 |
| 1183.45 | ||
| 1832.75 | ||
| 1818.73 | ||
| 1573.70 | ||
| 1645.47 | ||
| 1718.81 | ||
| 1788.73 | ||
| 508.00 | 1.53 | 1.53 |
| 585.63 | 1.25 | 1.25 |
| 444.92 | 2.23 | 2.23 |
| 1218.16 | ||
| 552.06 | 1.54 | 1.54 |
| 1285.25 | ||
| 1225.11 | ||
| 2514.44 | ||
| 761.17 | 6.65 | 6.65 |
| 1718.81 | ||
| 600.57 | 3.20 | 3.20 |
| 1261.14 | ||
| 1573.70 | ||
| 1686.57 | ||
| 1103.32 | ||
| 2047.40 | ||
| 1416.52 | ||
| 1137.43 | ||
| 1373.42 | ||
| 959.17 | 11.03 | 11.03 |
| 1905.85 | ||
| 1067.34 | ||
| 2572.53 | ||
| 1172.21 | ||
| 488.98 | 2.64 | 2.64 |
| 1191.52 | ||
| 557.10 | 1.99 | 1.99 |
| 2494.36 | ||
| 546.52 | 2.86 | 2.86 |
| 2798.70 | ||
| 1235.58 | ||
| 1427.47 | ||
| 1119.42 | ||
| 1339.46 | ||
| 1795.65 | ||
| 2093.06 | ||
| 1121.39 | ||
| 1225.54 | ||
| 1315.28 | ||
| 1145.07 | ||
| 1731.61 | ||
| 1285.32 | ||
| 1273.40 | ||
| 1147.47 | ||
| 1179.04 | ||
| 1311.40 | ||
| 1371.45 | ||
| 444.92 | 2.23 | 2.23 |
| 2180.18 | ||
| 602.58 | 3.43 | 3.43 |
| 1161.06 | ||
| 429.37 | 3.50 | 3.50 |
| 572.56 | 3.79 | 3.79 |
| 1105.39 | ||
| 1700.59 | ||
| 1349.25 | ||
| 372.49 | 2.86 | 2.86 |
| 1209.49 | ||
| 2033.42 | ||
| 2460.35 | ||
| 1282.36 | ||
| 1272.74 | ||
| 1351.65 | ||
| 1217.99 | ||
| 1863.77 | ||
| 1269.32 | ||
| 1263.54 | ||
| 1089.50 | ||
| 1416.52 | ||
| 1500.61 | ||
| 1118.43 | ||
| 1235.58 | ||
| 3035.86 | ||
| 1206.54 | ||
| 1217.99 | ||
| 1239.33 | ||
| 2592.47 | ||
| 1205.12 | ||
| 937.03 | 6.46 | 6.46 |
| 1147.47 | ||
| 1309.65 | ||
| 1744.65 | ||
| 1397.76 | ||
| 1815.77 | ||
| 2446.32 |