Basic Information
ID: ALA4257190
Type: Binding
Description: Inhibition of recombinant CYP17 (unknown origin) expressed in human AD293 cells assessed as reduction in [3H]-acetic acid level preincubated for 60 mins followed by [21-3H]17alpha-hydroxyl-Pregnenolone substrate addition measured after 4 hrs by TopCount method
Format: BAO_0000219
Organism: Homo sapiens
Target: Cytochrome P450 17A1(ALA3522)
Document: ALA4257084
Inhibition of recombinant CYP17 (unknown origin) expressed in human AD293 cells assessed as reduction in [3H]-acetic acid level preincubated for 60 mins followed by [21-3H]17alpha-hydroxyl-Pregnenolone substrate addition measured after 4 hrs by TopCount method: 38
Activity Charts
Bioactivity
Activity Types for Assay ALA4257190
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 571.07 | 3.93 | 3.93 |
| 598.10 | 3.42 | 3.42 |
| 571.07 | 3.93 | 3.93 |
| 461.95 | 5.08 | 5.08 |
| 668.60 | 5.06 | 5.06 |
| 547.08 | 3.10 | 3.10 |
| 540.06 | 3.83 | 3.83 |
| 469.97 | 3.86 | 3.86 |
| 511.02 | 3.69 | 3.69 |
| 598.10 | 3.42 | 3.42 |
| 644.58 | 4.58 | 4.58 |
| 607.56 | 4.29 | 4.29 |
| 727.59 | 6.08 | 6.08 |
| 644.02 | 4.76 | 4.76 |
| 547.08 | 3.10 | 3.10 |
| 511.02 | 3.69 | 3.69 |
| 469.97 | 3.86 | 3.86 |
| 609.58 | 4.54 | 4.54 |
| 633.56 | 3.91 | 3.91 |
| 545.47 | 4.34 | 4.34 |
| 545.47 | 4.34 | 4.34 |
| 496.39 | 5.74 | 5.74 |
| 595.55 | 4.15 | 4.15 |