Basic Information
ID: ALA4257285
Type: Binding
Description: Inhibition of recombinant human C-terminal FLAG-tagged FBXL10 (1 to 650 residues) expressed in baculovirus infected sf9 cells using H3K36me2-biotin peptide as substrate after 30 mins in presence of alpha-ketoglutaric acid by AlphaScreen assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4257285
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 203.20 | 1.18 | 1.18 |
| 309.33 | 2.86 | 2.86 |
| 349.39 | 3.64 | 3.64 |
| 227.23 | 0.66 | 0.66 |
| 372.22 | 3.48 | 3.48 |
| 337.77 | 2.83 | 2.83 |
| 337.32 | 2.17 | 2.17 |
| 337.77 | 2.83 | 2.83 |
| 285.35 | 3.22 | 3.22 |
| 353.81 | 4.37 | 4.37 |
| 311.32 | 3.03 | 3.03 |
| 357.80 | 3.90 | 3.90 |
| 305.34 | 2.98 | 2.98 |
| 324.39 | 1.50 | 1.50 |
| 350.42 | 3.08 | 3.08 |
| 407.83 | 5.15 | 5.15 |
| 282.10 | 1.94 | 1.94 |
| 297.29 | 2.83 | 2.83 |
| 313.74 | 3.50 | 3.50 |
| 361.32 | 3.90 | 3.90 |
| 304.35 | 1.22 | 1.22 |
| 343.77 | 3.51 | 3.51 |
| 363.42 | 3.94 | 3.94 |
| 350.42 | 3.08 | 3.08 |
| 364.40 | 3.06 | 3.06 |
| 280.29 | 2.09 | 2.09 |
| 367.38 | 3.78 | 3.78 |
| 323.35 | 2.89 | 2.89 |
| 313.74 | 3.50 | 3.50 |
| 357.42 | 3.25 | 3.25 |
| 336.34 | 2.28 | 2.28 |
| 355.83 | 4.27 | 4.27 |
| 337.77 | 2.83 | 2.83 |
| 297.29 | 2.83 | 2.83 |
| 421.86 | 5.35 | 5.35 |
| 367.42 | 3.52 | 3.52 |
| 401.35 | 3.11 | 3.11 |
| 327.77 | 3.54 | 3.54 |
| 302.33 | 0.97 | 0.97 |
| 337.35 | 3.86 | 3.86 |
| 297.29 | 2.83 | 2.83 |
| 354.38 | 2.91 | 2.91 |
| 300.36 | 1.99 | 1.99 |
| 231.25 | 2.05 | 2.05 |
| 350.42 | 3.00 | 3.00 |
| 381.74 | 4.52 | 4.52 |
| 375.44 | 3.21 | 3.21 |
| 310.37 | 1.22 | 1.22 |
| 307.35 | 3.19 | 3.19 |
| 389.81 | 4.14 | 4.14 |
| 393.43 | 3.65 | 3.65 |
| 404.39 | 3.79 | 3.79 |
| 357.42 | 2.93 | 2.93 |
| 336.40 | 2.78 | 2.78 |
| 297.29 | 2.99 | 2.99 |
| 303.32 | 2.83 | 2.83 |
| 351.80 | 3.02 | 3.02 |
| 368.82 | 3.31 | 3.31 |
| 375.79 | 3.75 | 3.75 |
| 396.88 | 3.96 | 3.96 |
| 319.36 | 3.72 | 3.72 |
| 371.38 | 3.62 | 3.62 |
| 343.39 | 2.54 | 2.54 |
| 318.34 | 3.33 | 3.33 |
| 431.32 | 4.61 | 4.61 |
| 293.33 | 3.25 | 3.25 |
| 273.29 | 1.82 | 1.82 |
| 454.47 | 3.40 | 3.40 |
| 323.35 | 3.25 | 3.25 |
| 385.35 | 3.39 | 3.39 |
| 321.38 | 3.89 | 3.89 |
| 331.73 | 3.64 | 3.64 |
| 546.01 | 5.65 | 5.65 |
| 351.80 | 2.84 | 2.84 |
| 361.38 | 3.34 | 3.34 |
| 356.81 | 3.43 | 3.43 |
| 451.92 | 3.85 | 3.85 |
| 391.41 | 3.26 | 3.26 |
| 258.28 | 1.18 | 1.18 |
| 345.36 | 3.03 | 3.03 |
| 347.30 | 3.71 | 3.71 |
| 323.33 | 3.32 | 3.32 |
| 272.31 | 1.40 | 1.40 |
| 348.19 | 4.15 | 4.15 |
| 322.37 | 2.78 | 2.78 |
| 347.30 | 3.87 | 3.87 |
| 389.32 | 3.49 | 3.49 |
| 372.22 | 3.48 | 3.48 |
| 445.89 | 4.83 | 4.83 |
| 368.82 | 3.31 | 3.31 |
| 333.39 | 3.76 | 3.76 |
| 427.44 | 4.05 | 4.05 |
| 300.36 | 1.99 | 1.99 |
| 331.38 | 3.12 | 3.12 |
| 300.36 | 1.99 | 1.99 |
| 307.35 | 3.41 | 3.41 |
| 385.37 | 3.91 | 3.91 |
| 363.30 | 3.75 | 3.75 |
| 293.33 | 3.16 | 3.16 |
| 462.34 | 5.34 | 5.34 |
| 359.39 | 2.53 | 2.53 |
| 359.79 | 4.51 | 4.51 |
| 402.38 | 3.68 | 3.68 |
| 380.42 | 3.45 | 3.45 |
| 388.83 | 3.66 | 3.66 |
| 353.39 | 3.33 | 3.33 |
| 299.37 | 3.61 | 3.61 |
| 345.41 | 3.37 | 3.37 |
| 356.81 | 3.09 | 3.09 |
| 348.41 | 3.10 | 3.10 |
| 503.93 | 4.63 | 4.63 |
| 307.35 | 3.45 | 3.45 |
| 431.86 | 4.63 | 4.63 |
| 368.41 | 3.30 | 3.30 |
| 405.77 | 3.85 | 3.85 |
| 409.84 | 2.82 | 2.82 |
| 283.29 | 1.54 | 1.54 |
| 352.37 | 2.80 | 2.80 |
| 300.32 | 1.27 | 1.27 |
| 382.85 | 3.75 | 3.75 |
| 311.32 | 3.03 | 3.03 |
| 351.80 | 3.39 | 3.39 |
| 501.95 | 5.42 | 5.42 |
| 334.38 | 2.66 | 2.66 |
| 279.30 | 2.69 | 2.69 |
| 400.87 | 5.25 | 5.25 |
| 307.35 | 3.64 | 3.64 |
| 348.19 | 4.15 | 4.15 |
| 377.84 | 3.86 | 3.86 |
| 355.40 | 4.36 | 4.36 |
| 286.34 | 1.91 | 1.91 |
| 427.44 | 4.05 | 4.05 |
| 367.38 | 3.78 | 3.78 |
| 309.32 | 2.86 | 2.86 |
| 327.77 | 3.54 | 3.54 |
| 366.40 | 3.24 | 3.24 |
| 354.39 | 2.91 | 2.91 |
| 343.39 | 4.04 | 4.04 |
| 352.37 | 2.85 | 2.85 |
| 309.33 | 2.34 | 2.34 |
| 297.29 | 2.99 | 2.99 |
| 387.33 | 3.07 | 3.07 |
| 352.39 | 2.44 | 2.44 |
| 381.74 | 4.52 | 4.52 |
| 419.34 | 3.41 | 3.41 |
| 340.36 | 2.57 | 2.57 |
| 361.41 | 2.77 | 2.77 |
| 440.44 | 3.72 | 3.72 |
| 286.34 | 1.74 | 1.74 |
| 323.33 | 3.32 | 3.32 |