Basic Information
ID: ALA4261452
Type: ADME
Description: Inhibition of human liver microsome CYP3A4 at 1 uM expressed in baculosomes using fluorogenic-DBOMF as substrate preincubated for 10 mins followed by substrate addition and measured after 60 mins by fluorescence based assay
Organism: Homo sapiens
Tissue: Liver
Subcellular Fraction: microsomes
Activity Charts
Bioactivity
Activity Types for Assay ALA4261452
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 705.65 | 5.58 | 5.58 |
| 732.71 | 6.80 | 6.80 |
| 736.74 | 5.53 | 5.53 |
| 718.69 | 6.49 | 6.49 |
| 780.76 | 7.85 | 7.85 |
| 786.68 | 7.51 | 7.51 |
| 714.69 | 7.53 | 7.53 |
| 717.49 | 6.68 | 6.68 |
| 773.64 | 6.60 | 6.60 |
| 652.62 | 6.70 | 6.70 |
| 706.64 | 4.97 | 4.97 |
| 732.71 | 6.80 | 6.80 |
| 782.73 | 6.64 | 6.64 |
| 722.72 | 5.19 | 5.19 |
| 719.67 | 5.89 | 5.89 |
| 732.71 | 6.74 | 6.74 |
| 704.66 | 6.18 | 6.18 |
| 718.69 | 6.49 | 6.49 |
| 681.67 | 5.85 | 5.85 |
| 704.66 | 6.18 | 6.18 |
| 624.57 | 6.13 | 6.13 |
| 706.72 | 7.87 | 7.87 |
| 706.64 | 4.97 | 4.97 |
| 720.66 | 5.28 | 5.28 |
| 723.70 | 5.62 | 5.62 |
| 733.70 | 6.19 | 6.19 |
| 746.74 | 7.31 | 7.31 |