Basic Information
ID: ALA4265578
Type: Binding
Description: Inhibition of JAK1/TYK2 in human PBMC assessed as reduction in IL10-induced STAT3 phosphorylation preincubated for 75 mins followed by IL10 addition and measured after 15 mins by FACS analysis
Organism: Homo sapiens
Cell type: PBMC
Activity Charts
Bioactivity
Activity Types for Assay ALA4265578
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 460.52 | 3.17 | 3.17 |
| 448.48 | 3.30 | 3.30 |
| 289.34 | 2.86 | 2.86 |
| 275.31 | 2.68 | 2.68 |
| 371.35 | 3.09 | 3.09 |
| 455.50 | 3.03 | 3.03 |
| 351.41 | 4.35 | 4.35 |
| 322.37 | 2.94 | 2.94 |
| 368.42 | 1.73 | 1.73 |
| 381.44 | 3.84 | 3.84 |
| 291.31 | 2.17 | 2.17 |