Basic Information
ID: ALA4266934
Type: Binding
Description: Agonist activity at TLR7 in human PBMC assessed as suppression of HCV replicon replication in human HuH7 luc/neo cells harboring RNA encoding bicistronic expression construct comprising wild type HCV type 1b NS3-NS5B regions exposed to conditioned media from compound treated PBMCs after 24 hrs by luciferase reporter gene assay
Format: BAO_0000219
Organism: Homo sapiens
Cell type: PBMC
Target: Toll-like receptor 7(ALA5936)
Document: ALA4265889
Agonist activity at TLR7 in human PBMC assessed as suppression of HCV replicon replication in human HuH7 luc/neo cells harboring RNA encoding bicistronic expression construct comprising wild type HCV type 1b NS3-NS5B regions exposed to conditioned media from compound treated PBMCs after 24 hrs by luciferase reporter gene assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4266934
MEC
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 312.42 | 2.22 | 2.22 |
| 390.51 | 1.99 | 1.99 |
| 303.41 | 1.96 | 1.96 |
| 327.39 | 1.26 | 1.26 |
| 333.42 | 1.32 | 1.32 |
| 332.43 | 1.93 | 1.93 |
| 389.53 | 2.67 | 2.67 |
| 380.32 | 4.14 | 4.14 |
| 361.49 | 3.98 | 3.98 |
| 301.39 | 2.42 | 2.42 |
| 331.44 | 2.53 | 2.53 |
| 341.46 | 2.84 | 2.84 |
| 330.39 | 1.77 | 1.77 |
| 375.90 | 3.49 | 3.49 |
| 345.88 | 3.48 | 3.48 |
| 367.54 | 4.13 | 4.13 |
| 312.42 | 2.22 | 2.22 |
| 291.40 | 1.81 | 1.81 |
| 404.54 | 2.38 | 2.38 |
| 346.46 | 2.23 | 2.23 |
| 326.40 | 1.86 | 1.86 |
| 312.42 | 2.22 | 2.22 |
| 326.40 | 1.86 | 1.86 |
| 350.47 | 3.31 | 3.31 |
| 346.46 | 2.23 | 2.23 |
| 341.42 | 1.57 | 1.57 |
| 347.45 | 1.51 | 1.51 |
| 375.50 | 2.28 | 2.28 |
| 347.41 | 3.11 | 3.11 |
| 387.53 | 4.50 | 4.50 |
| 395.43 | 3.73 | 3.73 |
| 317.46 | 2.89 | 2.89 |
| 316.36 | 1.46 | 1.46 |
| 277.37 | 1.57 | 1.57 |
| 347.45 | 1.51 | 1.51 |
| 380.32 | 4.14 | 4.14 |
| 379.43 | 3.85 | 3.85 |