Basic Information
ID: ALA4268297
Type: Binding
Description: Antagonist activity at human TRPA1 expressed in HEK293 cells assessed as decrease in flufenamic acid-evoked increase in intracellular calcium level at 100 uM measured for 180 secs with 1 sec interval by Fluo4-AM dye-based fluorescence assay relative to control
Format: BAO_0000219
Organism: Homo sapiens
Cell type: HEK293
Target: Transient receptor potential cation channel subfamily A member 1(ALA6007)
Document: ALA4265944
Antagonist activity at human TRPA1 expressed in HEK293 cells assessed as decrease in flufenamic acid-evoked increase in intracellular calcium level at 100 uM measured for 180 secs with 1 sec interval by Fluo4-AM dye-based fluorescence assay relative to control: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4268297
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 355.40 | 1.20 | 1.20 |
| 399.45 | 1.38 | 1.38 |
| 391.82 | 1.12 | 1.12 |
| 391.82 | 0.41 | 0.41 |
| 427.51 | 2.16 | 2.16 |
| 405.84 | 0.80 | 0.80 |
| 455.56 | 3.15 | 3.15 |
| 419.87 | 1.19 | 1.19 |
| 377.79 | 0.73 | 0.73 |
| 455.56 | 2.94 | 2.94 |
| 391.82 | 1.12 | 1.12 |
| 385.42 | 1.20 | 1.20 |
| 427.51 | 2.37 | 2.37 |
| 485.59 | 3.03 | 3.03 |
| 413.48 | 1.77 | 1.77 |
| 405.84 | 1.51 | 1.51 |
| 471.56 | 2.64 | 2.64 |
| 405.84 | 1.51 | 1.51 |
| 441.53 | 2.55 | 2.55 |
| 441.53 | 2.76 | 2.76 |
| 469.59 | 3.55 | 3.55 |
| 399.45 | 1.59 | 1.59 |
| 413.48 | 1.98 | 1.98 |