Basic Information
ID: ALA4269689
Type: ADME
Description: Inhibition of CYP2D6 in human liver microsomes using midazolam as substrate preincubated for 15 mins followed by substrate addition and measured after 30 mins in presence of NADPH by LC-MS analysis
Organism: Homo sapiens
Tissue: Liver
Subcellular Fraction: microsomes
Activity Charts
Bioactivity
Activity Types for Assay ALA4269689
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 416.48 | 2.63 | 2.63 |
| 412.52 | 2.88 | 2.88 |
| 424.53 | 3.03 | 3.03 |
| 398.49 | 2.50 | 2.50 |
| 399.48 | 1.89 | 1.89 |
| 455.54 | 1.85 | 1.85 |
| 441.56 | 2.75 | 2.75 |
| 399.48 | 1.89 | 1.89 |
| 413.50 | 2.28 | 2.28 |
| 412.52 | 2.86 | 2.86 |
| 395.48 | 3.46 | 3.46 |
| 442.55 | 2.12 | 2.12 |
| 414.49 | 1.27 | 1.27 |