Basic Information
ID: ALA4270027
Type: ADME
Description: Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate preincubated for 30 mins followed by substrate/NADPH addition measured after 10 mins by LC-MS/MS analysis
Organism: Homo sapiens
Tissue: Liver
Subcellular Fraction: microsomes
Activity Charts
Bioactivity
Activity Types for Assay ALA4270027
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 445.52 | 3.75 | 3.75 |
| 446.51 | 3.15 | 3.15 |
| 429.51 | 2.40 | 2.40 |
| 447.50 | 2.54 | 2.54 |
| 477.53 | 2.55 | 2.55 |
| 505.58 | 3.33 | 3.33 |
| 532.61 | 2.38 | 2.38 |
| 477.53 | 2.55 | 2.55 |
| 475.55 | 3.11 | 3.11 |
| 456.93 | 3.33 | 3.33 |
| 425.29 | 1.77 | 1.77 |
| 516.61 | 3.14 | 3.14 |
| 465.49 | 2.68 | 2.68 |
| 465.49 | 2.68 | 2.68 |
| 475.55 | 3.16 | 3.16 |
| 461.53 | 2.85 | 2.85 |
| 458.47 | 2.95 | 2.95 |
| 491.55 | 2.86 | 2.86 |
| 491.55 | 2.94 | 2.94 |
| 481.94 | 3.20 | 3.20 |