Basic Information
ID: ALA4272239
Type: Binding
Description: Inhibition of mouse full length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated for 1 hr followed by substrate addition measured after 25 mins
Format: BAO_0000357
Organism: Mus musculus
Target: Serine/threonine-protein kinase B-raf(ALA2331061)
Document: ALA4270537
Inhibition of mouse full length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated for 1 hr followed by substrate addition measured after 25 mins: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4272239
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 489.93 | 5.54 | 5.54 |
| 429.55 | 5.31 | 5.31 |
| 445.54 | 5.01 | 5.01 |
| 415.52 | 5.01 | 5.01 |
| 445.54 | 5.01 | 5.01 |
| 484.41 | 6.31 | 6.31 |
| 449.96 | 5.66 | 5.66 |
| 460.52 | 4.91 | 4.91 |
| 449.96 | 5.66 | 5.66 |
| 421.55 | 5.07 | 5.07 |
| 433.51 | 5.15 | 5.15 |
| 483.52 | 6.02 | 6.02 |
| 494.41 | 5.77 | 5.77 |
| 494.41 | 5.77 | 5.77 |
| 461.61 | 5.73 | 5.73 |
| 443.57 | 5.62 | 5.62 |
| 521.64 | 6.58 | 6.58 |