Basic Information
ID: ALA4272246
Type: Binding
Description: Inhibition of recombinant human GST-tagged c-RAF (306 to 648 residues) Y340D/Y341D mutant expressed in baculovirus expression system using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated for 1 hr followed by substrate addition measured after 25 mins
Format: BAO_0000019
Organism: Homo sapiens
Target: Serine/threonine-protein kinase RAF(ALA1906)
Document: ALA4270537
Inhibition of recombinant human GST-tagged c-RAF (306 to 648 residues) Y340D/Y341D mutant expressed in baculovirus expression system using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated for 1 hr followed by substrate addition measured after 25 mins: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4272246
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 445.54 | 5.01 | 5.01 |
| 494.41 | 5.77 | 5.77 |
| 521.64 | 6.58 | 6.58 |