Basic Information
ID: ALA4273596
Type: Binding
Description: Inhibition of mPGES-1 isolated from microsomes of interleukin-1 beta-stimulated human A549 cells using PGH2 as substrate preincubated for 15 mins followed by substrate addition measured after 1 min by RP-HPLC analysis
Organism: Homo sapiens
Subcellular Fraction: Microsomes
Activity Charts
Bioactivity
Activity Types for Assay ALA4273596
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 236.30 | 2.73 | 2.73 |
| 403.54 | 5.25 | 5.25 |
| 463.58 | 7.20 | 7.20 |
| 443.59 | 6.83 | 6.83 |
| 521.64 | 6.92 | 6.92 |
| 507.61 | 6.53 | 6.53 |
| 473.55 | 5.88 | 5.88 |
| 513.59 | 7.48 | 7.48 |
| 465.57 | 5.95 | 5.95 |
| 437.50 | 5.91 | 5.91 |
| 465.62 | 6.61 | 6.61 |
| 520.63 | 4.51 | 4.51 |
| 501.56 | 5.22 | 5.22 |
| 467.61 | 6.93 | 6.93 |
| 449.57 | 5.83 | 5.83 |
| 493.58 | 6.60 | 6.60 |
| 513.59 | 7.48 | 7.48 |
| 551.62 | 7.36 | 7.36 |
| 457.53 | 7.05 | 7.05 |
| 499.57 | 7.69 | 7.69 |
| 494.57 | 6.00 | 6.00 |
| 449.55 | 5.51 | 5.51 |
| 457.55 | 5.76 | 5.76 |
| 443.52 | 5.45 | 5.45 |
| 472.09 | 8.01 | 8.01 |
| 487.53 | 5.18 | 5.18 |
| 437.56 | 5.83 | 5.83 |
| 450.34 | 5.40 | 5.40 |