Basic Information
ID: ALA4304842
Type: Binding
Description: Inhibition of MD2-TLR4 protein-protein interaction in ICR mouse peritoneal macrophages assessed as reduction in LPS-induced TNFalpha production at 10 uM preincubated for 2 hrs followed by LPS-stimulation and measured after 22 hrs by ELISA relative to control
Organism: Mus musculus
Strain: ICR
Activity Charts
Bioactivity
Activity Types for Assay ALA4304842
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 375.48 | 3.14 | 3.14 |
| 410.48 | 4.74 | 4.74 |
| 422.49 | 4.83 | 4.83 |
| 322.32 | 3.09 | 3.09 |
| 382.85 | 3.74 | 3.74 |
| 430.90 | 5.08 | 5.08 |
| 348.41 | 3.53 | 3.53 |
| 397.44 | 3.82 | 3.82 |
| 334.38 | 3.14 | 3.14 |
| 421.29 | 6.27 | 6.27 |
| 411.47 | 4.13 | 4.13 |
| 292.34 | 2.76 | 2.76 |
| 456.50 | 4.45 | 4.45 |
| 414.44 | 4.57 | 4.57 |
| 465.34 | 5.74 | 5.74 |