Basic Information
ID: ALA4305726
Type: Functional
Description: Anti-osteoporosis activity in C57BL/6 mouse bone marrow macrophages assessed as inhibition of M-CSF/RANKL-induced osteoclast differentiation supplemented with fresh medium containing compounds every 2 days for 5 measured post-last dose by TRAP staining based assay
Organism: Mus musculus
Strain: C57BL/6
Cell type: BMDM
Activity Charts
Bioactivity
Activity Types for Assay ALA4305726
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 262.29 | 2.43 | 2.43 |
| 247.32 | 2.37 | 2.37 |
| 269.26 | 2.32 | 2.32 |
| 315.35 | 2.40 | 2.40 |
| 298.37 | 4.27 | 4.27 |
| 301.28 | 2.02 | 2.02 |
| 317.35 | 2.49 | 2.49 |
| 344.36 | 2.26 | 2.26 |
| 360.40 | 3.07 | 3.07 |
| 289.32 | 1.94 | 1.94 |
| 322.41 | 3.05 | 3.05 |
| 310.34 | 1.91 | 1.91 |
| 329.38 | 2.83 | 2.83 |
| 300.35 | 1.74 | 1.74 |
| 333.80 | 3.00 | 3.00 |
| 328.29 | 1.79 | 1.79 |
| 229.26 | 2.27 | 2.27 |
| 350.41 | 2.78 | 2.78 |
| 389.41 | 2.66 | 2.66 |
| 322.35 | 3.66 | 3.66 |
| 291.36 | 2.10 | 2.10 |
| 365.42 | 3.20 | 3.20 |
| 309.35 | 2.02 | 2.02 |
| 315.36 | 2.05 | 2.05 |
| 353.38 | 3.33 | 3.33 |
| 377.45 | 2.59 | 2.59 |
| 405.87 | 3.18 | 3.18 |
| 319.78 | 2.69 | 2.69 |
| 286.32 | 1.44 | 1.44 |
| 317.74 | 2.53 | 2.53 |
| 372.41 | 1.92 | 1.92 |
| 305.39 | 2.41 | 2.41 |
| 319.78 | 2.69 | 2.69 |
| 336.41 | 3.59 | 3.59 |
| 302.36 | 3.14 | 3.14 |
| 317.74 | 2.53 | 2.53 |
| 405.87 | 3.18 | 3.18 |
| 284.28 | 1.28 | 1.28 |
| 477.49 | 5.77 | 5.77 |
| 319.78 | 2.69 | 2.69 |
| 320.37 | 2.92 | 2.92 |
| 357.40 | 2.14 | 2.14 |
| 333.80 | 3.00 | 3.00 |
| 314.37 | 1.93 | 1.93 |
| 461.47 | 3.03 | 3.03 |
| 329.39 | 2.36 | 2.36 |
| 313.32 | 1.89 | 1.89 |
| 343.37 | 2.05 | 2.05 |
| 330.33 | 1.95 | 1.95 |
| 307.31 | 1.86 | 1.86 |
| 284.38 | 4.63 | 4.63 |
| 393.43 | 2.98 | 2.98 |
| 416.42 | 2.43 | 2.43 |
| 380.39 | 3.10 | 3.10 |
| 443.47 | 5.63 | 5.63 |
| 369.84 | 3.85 | 3.85 |
| 300.35 | 1.62 | 1.62 |
| 341.42 | 3.26 | 3.26 |
| 446.47 | 4.25 | 4.25 |
| 341.33 | 1.67 | 1.67 |
| 369.84 | 3.85 | 3.85 |
| 308.30 | 1.75 | 1.75 |
| 317.74 | 2.53 | 2.53 |
| 396.43 | 2.40 | 2.40 |
| 508.50 | 4.32 | 4.32 |
| 336.38 | 2.59 | 2.59 |
| 262.33 | 3.18 | 3.18 |
| 401.45 | 2.53 | 2.53 |
| 303.32 | 2.18 | 2.18 |