Basic Information
ID: ALA4306813
Type: Functional
Description: Agonist activity at human Muscarinic acetylcholine receptor M4 expressed in HEK cells co-expressing Glosensor construct assessed as decrease in isoproterenol-induced cAMP accumulation at 10 uM to 0.3 nM incubated for 2 hrs in presence of isoproterenol and measured after 7 mins by Glosensor cAMP reagent/plate reader based luminescence assay relative to acetylcholine
Format: BAO_0000219
Organism: Homo sapiens
Target: Muscarinic acetylcholine receptor M4(ALA1821)
Document: ALA4304767
Agonist activity at human Muscarinic acetylcholine receptor M4 expressed in HEK cells co-expressing Glosensor construct assessed as decrease in isoproterenol-induced cAMP accumulation at 10 uM to 0.3 nM incubated for 2 hrs in presence of isoproterenol and measured after 7 mins by Glosensor cAMP reagent/plate reader based luminescence assay relative to acetylcholine: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4306813
Emax
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 206.29 | 0.71 | 0.71 |
| 281.42 | 3.22 | 3.22 |
| 361.49 | 3.14 | 3.14 |
| 373.53 | 3.18 | 3.18 |
| 381.52 | 3.43 | 3.43 |
| 387.55 | 3.49 | 3.49 |
| 367.50 | 3.12 | 3.12 |
| 361.49 | 3.28 | 3.28 |
| 403.55 | 3.19 | 3.19 |
| 381.52 | 3.43 | 3.43 |
| 412.54 | 3.37 | 3.37 |
| 367.50 | 2.98 | 2.98 |
| 379.51 | 3.12 | 3.12 |
| 373.50 | 3.28 | 3.28 |
| 373.53 | 3.18 | 3.18 |
| 406.53 | 3.53 | 3.53 |
| 381.52 | 3.43 | 3.43 |