Basic Information
ID: ALA4308446
Type: Binding
Description: Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system at 10 uM preincubated with enzyme/ATP mixture for 20 mins followed by TK substrate-biotin addition followed by further incubation for 15 mins in presence of ATP by HTRF assay relative to control
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4308446
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 478.48 | 4.73 | 4.73 |
| 484.56 | 3.81 | 3.81 |
| 386.46 | 5.00 | 5.00 |
| 472.98 | 4.75 | 4.75 |
| 424.43 | 6.01 | 6.01 |
| 416.48 | 5.01 | 5.01 |
| 484.56 | 3.81 | 3.81 |
| 428.49 | 5.21 | 5.21 |
| 402.47 | 5.62 | 5.62 |
| 496.57 | 3.97 | 3.97 |
| 452.57 | 4.41 | 4.41 |
| 370.46 | 5.30 | 5.30 |
| 484.56 | 3.81 | 3.81 |
| 484.56 | 3.81 | 3.81 |
| 442.50 | 3.93 | 3.93 |
| 470.61 | 4.51 | 4.51 |
| 430.51 | 5.02 | 5.02 |
| 435.33 | 5.75 | 5.75 |
| 452.57 | 4.41 | 4.41 |
| 470.61 | 4.51 | 4.51 |
| 482.55 | 3.58 | 3.58 |
| 422.89 | 5.80 | 5.80 |
| 464.95 | 5.67 | 5.67 |
| 468.56 | 4.19 | 4.19 |
| 442.50 | 3.93 | 3.93 |
| 444.54 | 5.50 | 5.50 |
| 452.57 | 4.41 | 4.41 |
| 412.54 | 6.10 | 6.10 |
| 412.54 | 6.10 | 6.10 |
| 452.57 | 4.41 | 4.41 |
| 398.51 | 5.79 | 5.79 |
| 452.57 | 4.41 | 4.41 |
| 472.98 | 4.75 | 4.75 |
| 435.33 | 5.75 | 5.75 |
| 430.51 | 5.02 | 5.02 |
| 434.93 | 5.66 | 5.66 |
| 446.55 | 6.76 | 6.76 |
| 492.51 | 4.81 | 4.81 |
| 472.98 | 4.75 | 4.75 |
| 492.51 | 4.81 | 4.81 |
| 476.95 | 4.58 | 4.58 |
| 418.93 | 6.14 | 6.14 |
| 420.90 | 5.65 | 5.65 |
| 484.56 | 3.81 | 3.81 |
| 424.51 | 3.79 | 3.79 |
| 452.57 | 4.35 | 4.35 |
| 442.50 | 3.93 | 3.93 |
| 438.54 | 4.10 | 4.10 |
| 444.54 | 5.50 | 5.50 |
| 454.54 | 3.80 | 3.80 |
| 418.93 | 5.96 | 5.96 |
| 492.51 | 4.81 | 4.81 |
| 478.98 | 6.16 | 6.16 |
| 424.51 | 4.02 | 4.02 |
| 452.57 | 4.41 | 4.41 |
| 476.58 | 6.85 | 6.85 |
| 454.54 | 3.80 | 3.80 |
| 438.54 | 4.27 | 4.27 |
| 388.45 | 5.44 | 5.44 |
| 454.54 | 3.80 | 3.80 |
| 442.50 | 3.93 | 3.93 |
| 458.96 | 4.44 | 4.44 |
| 398.51 | 5.79 | 5.79 |
| 404.90 | 5.66 | 5.66 |
| 449.35 | 5.77 | 5.77 |
| 430.51 | 5.02 | 5.02 |
| 454.54 | 3.80 | 3.80 |
| 472.98 | 4.75 | 4.75 |
| 404.90 | 5.95 | 5.95 |
| 384.48 | 5.61 | 5.61 |
| 484.56 | 3.81 | 3.81 |
| 472.98 | 4.75 | 4.75 |
| 462.92 | 4.27 | 4.27 |
| 418.93 | 6.14 | 6.14 |
| 428.54 | 5.80 | 5.80 |
| 410.48 | 3.71 | 3.71 |
| 412.54 | 6.10 | 6.10 |
| 428.54 | 5.88 | 5.88 |
| 414.51 | 5.40 | 5.40 |
| 452.57 | 4.35 | 4.35 |
| 438.54 | 4.10 | 4.10 |
| 492.51 | 4.81 | 4.81 |
| 398.51 | 5.62 | 5.62 |
| 414.51 | 5.49 | 5.49 |
| 482.55 | 3.58 | 3.58 |
| 438.54 | 4.10 | 4.10 |
| 402.52 | 5.71 | 5.71 |
| 492.51 | 4.81 | 4.81 |
| 438.45 | 6.02 | 6.02 |
| 496.57 | 3.97 | 3.97 |
| 472.98 | 4.75 | 4.75 |
| 416.48 | 5.01 | 5.01 |
| 390.87 | 5.65 | 5.65 |
| 474.56 | 5.51 | 5.51 |
| 438.54 | 4.10 | 4.10 |
| 438.45 | 6.02 | 6.02 |
| 444.93 | 4.36 | 4.36 |
| 438.54 | 4.10 | 4.10 |
| 388.45 | 5.14 | 5.14 |
| 456.53 | 4.24 | 4.24 |
| 460.49 | 4.07 | 4.07 |
| 468.56 | 4.11 | 4.11 |
| 442.50 | 3.93 | 3.93 |
| 404.90 | 5.66 | 5.66 |
| 384.48 | 5.61 | 5.61 |
| 370.46 | 5.30 | 5.30 |
| 398.51 | 5.62 | 5.62 |
| 454.54 | 3.80 | 3.80 |
| 416.55 | 5.72 | 5.72 |
| 462.92 | 4.50 | 4.50 |
| 428.47 | 3.62 | 3.62 |
| 426.52 | 5.69 | 5.69 |
| 424.51 | 3.79 | 3.79 |
| 456.53 | 4.24 | 4.24 |
| 438.54 | 4.10 | 4.10 |
| 446.51 | 5.02 | 5.02 |
| 448.95 | 6.15 | 6.15 |
| 400.48 | 5.31 | 5.31 |
| 398.51 | 5.62 | 5.62 |
| 430.58 | 6.21 | 6.21 |