Basic Information
ID: ALA4309002
Type: Binding
Description: Negative allosteric modulation of human GluN2A receptor expressed in HEK cells assessed as reduction in 3 uM glycine/glutamate-induced intracellular calcium flux preincubated for 10 mins followed by glycine/glutamate addition and measured for 3 mins by Fluo-8-AM dye based fluorescence assay
Format: BAO_0000219
Organism: Homo sapiens
Target: Glutamate [NMDA] receptor subunit epsilon 1(ALA1972)
Document: ALA4308825
Negative allosteric modulation of human GluN2A receptor expressed in HEK cells assessed as reduction in 3 uM glycine/glutamate-induced intracellular calcium flux preincubated for 10 mins followed by glycine/glutamate addition and measured for 3 mins by Fluo-8-AM dye based fluorescence assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4309002
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 461.90 | 3.03 | 3.03 |
| 470.94 | 1.95 | 1.95 |
| 468.51 | 1.74 | 1.74 |