Basic Information
ID: ALA4309086
Type: Binding
Description: Positive allosteric modulation of human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as increase in acetylcholine-induced channel current at -90 mV holding potential preincubated for 2 mins followed by co-application with acetylcholine for 10 secs by two-electrode voltage clamp method
Format: BAO_0000219
Organism: Homo sapiens
Target: Neuronal acetylcholine receptor protein alpha-7 subunit(ALA2492)
Document: ALA4308829
Positive allosteric modulation of human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as increase in acetylcholine-induced channel current at -90 mV holding potential preincubated for 2 mins followed by co-application with acetylcholine for 10 secs by two-electrode voltage clamp method: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4309086
EC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 370.83 | 3.34 | 3.34 |
| 417.32 | 5.51 | 5.51 |
| 417.92 | 5.24 | 5.24 |
| 369.45 | 4.27 | 4.27 |
| 386.84 | 4.69 | 4.69 |
| 396.90 | 5.16 | 5.16 |
| 399.93 | 5.10 | 5.10 |
| 427.98 | 5.53 | 5.53 |
| 403.29 | 5.20 | 5.20 |
| 396.90 | 4.88 | 4.88 |
| 399.93 | 5.26 | 5.26 |
| 385.90 | 4.79 | 4.79 |
| 386.84 | 4.69 | 4.69 |
| 382.88 | 4.86 | 4.86 |
| 429.95 | 5.10 | 5.10 |
| 369.45 | 4.27 | 4.27 |
| 396.90 | 4.72 | 4.72 |
| 334.83 | 3.63 | 3.63 |
| 404.83 | 4.83 | 4.83 |
| 419.30 | 4.30 | 4.30 |
| 435.91 | 5.37 | 5.37 |
| 385.90 | 4.79 | 4.79 |
| 413.96 | 5.14 | 5.14 |
| 413.96 | 5.40 | 5.40 |
| 478.82 | 5.86 | 5.86 |
| 403.29 | 5.20 | 5.20 |
| 382.88 | 4.42 | 4.42 |
| 410.89 | 4.36 | 4.36 |
| 417.92 | 5.24 | 5.24 |
| 405.27 | 3.99 | 3.99 |
| 452.85 | 5.45 | 5.45 |
| 396.90 | 5.11 | 5.11 |
| 367.86 | 4.78 | 4.78 |
| 398.88 | 4.56 | 4.56 |
| 405.27 | 3.99 | 3.99 |
| 447.75 | 5.31 | 5.31 |
| 434.37 | 5.75 | 5.75 |
| 410.93 | 5.47 | 5.47 |
| 400.87 | 5.00 | 5.00 |
| 398.94 | 6.08 | 6.08 |
| 396.90 | 5.16 | 5.16 |
| 417.92 | 5.24 | 5.24 |
| 369.84 | 3.94 | 3.94 |
| 365.48 | 4.44 | 4.44 |
| 369.45 | 4.27 | 4.27 |
| 375.86 | 5.40 | 5.40 |
| 382.88 | 4.86 | 4.86 |
| 368.85 | 4.55 | 4.55 |
| 382.88 | 4.86 | 4.86 |
| 386.84 | 4.69 | 4.69 |
| 446.94 | 3.91 | 3.91 |