Basic Information
ID: ALA4309191
Type: Binding
Description: Antagonist activity at prolink-tagged TrkA (unknown origin) expressed in cells assessed as inhibition of NGF-induced receptor phosphorylation by measuring reduction in EA-tagged SH2 protein recruitment preincubated for 30 mins followed by NGF addition measured after 2 hrs by PathHunter enzyme complementation assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4309191
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 346.22 | 4.74 | 4.74 |
| 524.41 | 4.99 | 4.99 |
| 435.85 | 4.08 | 4.08 |
| 474.91 | 3.90 | 3.90 |
| 508.37 | 4.62 | 4.62 |
| 452.30 | 4.59 | 4.59 |
| 525.94 | 4.62 | 4.62 |
| 447.88 | 3.95 | 3.95 |
| 495.37 | 4.18 | 4.18 |
| 496.35 | 4.22 | 4.22 |
| 435.85 | 4.08 | 4.08 |
| 431.88 | 4.25 | 4.25 |
| 453.84 | 4.22 | 4.22 |
| 529.91 | 4.58 | 4.58 |
| 467.86 | 4.88 | 4.88 |
| 460.88 | 3.04 | 3.04 |
| 452.30 | 4.59 | 4.59 |
| 483.86 | 4.54 | 4.54 |
| 514.34 | 4.35 | 4.35 |
| 457.92 | 4.82 | 4.82 |
| 432.87 | 3.52 | 3.52 |
| 542.40 | 5.13 | 5.13 |
| 445.91 | 4.54 | 4.54 |
| 467.32 | 4.17 | 4.17 |
| 467.32 | 4.17 | 4.17 |