Basic Information
ID: ALA4310037
Type: Functional
Description: Positive allosteric modulation of human mGlu4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium mobilization preincubated for 142 secs followed by EC20 glutamate addition and subsequent EC80 glutamate addition after 147 secs by Fluo-4-AM dye based fluorescence assay
Format: BAO_0000219
Organism: Homo sapiens
Cell type: CHO
Target: Metabotropic glutamate receptor 4(ALA2736)
Document: ALA4308847
Positive allosteric modulation of human mGlu4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium mobilization preincubated for 142 secs followed by EC20 glutamate addition and subsequent EC80 glutamate addition after 147 secs by Fluo-4-AM dye based fluorescence assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4310037
EC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 304.36 | 3.47 | 3.47 |
| 322.37 | 3.83 | 3.83 |
| 319.37 | 4.50 | 4.50 |
| 306.33 | 3.51 | 3.51 |
| 305.34 | 4.11 | 4.11 |
| 380.43 | 2.78 | 2.78 |
| 323.43 | 4.61 | 4.61 |
| 266.26 | 2.55 | 2.55 |
| 392.49 | 4.18 | 4.18 |
| 320.36 | 3.90 | 3.90 |
| 337.45 | 4.90 | 4.90 |
| 283.27 | 3.29 | 3.29 |
| 319.37 | 4.50 | 4.50 |
| 321.38 | 4.43 | 4.43 |
| 308.37 | 3.58 | 3.58 |
| 265.28 | 3.15 | 3.15 |
| 325.40 | 3.54 | 3.54 |
| 321.38 | 4.75 | 4.75 |
| 284.25 | 2.69 | 2.69 |
| 315.28 | 3.95 | 3.95 |
| 265.28 | 3.15 | 3.15 |
| 307.36 | 4.04 | 4.04 |
| 283.27 | 3.29 | 3.29 |
| 283.27 | 3.29 | 3.29 |
| 279.30 | 3.41 | 3.41 |
| 401.45 | 3.94 | 3.94 |
| 307.38 | 4.19 | 4.19 |
| 401.40 | 3.23 | 3.23 |
| 408.49 | 3.56 | 3.56 |
| 400.41 | 3.79 | 3.79 |
| 414.44 | 4.18 | 4.18 |
| 265.28 | 3.15 | 3.15 |
| 414.44 | 4.18 | 4.18 |
| 321.38 | 4.43 | 4.43 |
| 295.37 | 3.87 | 3.87 |
| 293.33 | 3.97 | 3.97 |
| 321.38 | 4.75 | 4.75 |
| 338.44 | 4.29 | 4.29 |
| 339.43 | 3.69 | 3.69 |
| 337.45 | 4.90 | 4.90 |
| 418.53 | 4.43 | 4.43 |
| 321.38 | 4.75 | 4.75 |
| 295.37 | 3.87 | 3.87 |
| 283.27 | 3.29 | 3.29 |
| 335.31 | 4.33 | 4.33 |
| 406.52 | 4.43 | 4.43 |
| 322.37 | 4.14 | 4.14 |
| 279.30 | 3.41 | 3.41 |
| 400.41 | 3.84 | 3.84 |
| 392.49 | 4.04 | 4.04 |