Basic Information
ID: ALA4310040
Type: ADME
Description: Intrinsic clearance in human liver microsomes at 1 uM preincubated for 5 mins followed by NADPH addition measured up to 45 mins by LC-MS/MS analysis
Format: BAO_0000251
Organism: Homo sapiens
Tissue: Liver
Subcellular Fraction: Microsome
Target: ADMET(ALA612558)
Document: ALA4308847
Intrinsic clearance in human liver microsomes at 1 uM preincubated for 5 mins followed by NADPH addition measured up to 45 mins by LC-MS/MS analysis: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4310040
CL
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 322.37 | 3.83 | 3.83 |
| 319.37 | 4.50 | 4.50 |
| 305.34 | 4.11 | 4.11 |
| 380.43 | 2.78 | 2.78 |
| 266.26 | 2.55 | 2.55 |
| 320.36 | 3.90 | 3.90 |
| 283.27 | 3.29 | 3.29 |
| 308.37 | 3.58 | 3.58 |
| 315.28 | 3.95 | 3.95 |
| 265.28 | 3.15 | 3.15 |
| 283.27 | 3.29 | 3.29 |
| 283.27 | 3.29 | 3.29 |
| 401.45 | 3.94 | 3.94 |
| 307.38 | 4.19 | 4.19 |
| 401.40 | 3.23 | 3.23 |
| 408.49 | 3.56 | 3.56 |
| 414.44 | 4.18 | 4.18 |
| 265.28 | 3.15 | 3.15 |
| 414.44 | 4.18 | 4.18 |
| 321.38 | 4.43 | 4.43 |
| 295.37 | 3.87 | 3.87 |
| 321.38 | 4.75 | 4.75 |
| 338.44 | 4.29 | 4.29 |
| 339.43 | 3.69 | 3.69 |
| 283.27 | 3.29 | 3.29 |
| 279.30 | 3.41 | 3.41 |
| 400.41 | 3.84 | 3.84 |
| 392.49 | 4.04 | 4.04 |