Basic Information
ID: ALA4310376
Type: Binding
Description: Silent agonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as increase in net charge at 30 uM at -60 mV holding potential treated for 12 secs followed by compound washout for 181 secs in presence of type 2 PAM PNU-120596 by whole cell two electrode voltage-clamp assay relative to ACh
Format: BAO_0000219
Organism: Homo sapiens
Target: Neuronal acetylcholine receptor protein alpha-7 subunit(ALA2492)
Document: ALA4308856
Silent agonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as increase in net charge at 30 uM at -60 mV holding potential treated for 12 secs followed by compound washout for 181 secs in presence of type 2 PAM PNU-120596 by whole cell two electrode voltage-clamp assay relative to ACh: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4310376
FC
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 415.45 | 2.63 | 2.63 |
| 399.45 | 2.93 | 2.93 |
| 385.42 | 2.62 | 2.62 |
| 464.32 | 3.38 | 3.38 |
| 441.31 | 2.77 | 2.77 |
| 375.38 | 2.21 | 2.21 |
| 537.18 | 3.37 | 3.37 |
| 386.41 | 2.02 | 2.02 |
| 403.41 | 2.76 | 2.76 |
| 415.45 | 2.63 | 2.63 |
| 412.28 | 2.16 | 2.16 |
| 429.28 | 2.90 | 2.90 |
| 490.18 | 3.53 | 3.53 |
| 453.42 | 3.64 | 3.64 |
| 386.41 | 2.02 | 2.02 |
| 417.32 | 2.83 | 2.83 |
| 441.31 | 2.77 | 2.77 |
| 419.87 | 3.27 | 3.27 |
| 349.22 | 1.41 | 1.41 |
| 479.28 | 3.78 | 3.78 |
| 511.32 | 3.23 | 3.23 |
| 401.25 | 2.36 | 2.36 |
| 323.35 | 1.26 | 1.26 |
| 445.73 | 3.42 | 3.42 |
| 425.31 | 3.07 | 3.07 |
| 411.29 | 2.77 | 2.77 |
| 391.45 | 2.68 | 2.68 |
| 412.28 | 2.16 | 2.16 |