Basic Information
ID: ALA4310379
Type: Binding
Description: Silent agonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as increase in net charge at 3 to 10 uM at -60 mV holding potential treated for 12 secs followed by compound washout for 181 secs in presence of type 2 PAM PNU-120596 by whole cell two electrode voltage-clamp assay relative to ACh
Format: BAO_0000219
Organism: Homo sapiens
Target: Neuronal acetylcholine receptor protein alpha-7 subunit(ALA2492)
Document: ALA4308856
Silent agonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as increase in net charge at 3 to 10 uM at -60 mV holding potential treated for 12 secs followed by compound washout for 181 secs in presence of type 2 PAM PNU-120596 by whole cell two electrode voltage-clamp assay relative to ACh: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4310379
FC
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 441.31 | 2.77 | 2.77 |
| 425.31 | 3.07 | 3.07 |