Basic Information
ID: ALA4310453
Type: Functional
Description: Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobilization at 30 uM preincubated for 2.3 mins followed by glutamate addition and measured after 1.7 mins by Fluo-4-AM dye based fluorescence assay relative to control
Organism: Rattus norvegicus
Cell type: HEK293
Activity Charts
Bioactivity
Activity Types for Assay ALA4310453
Emax
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 431.35 | 3.63 | 3.63 |
| 409.44 | 4.18 | 4.18 |
| 397.41 | 4.31 | 4.31 |
| 413.86 | 4.83 | 4.83 |
| 409.44 | 4.18 | 4.18 |
| 371.44 | 3.03 | 3.03 |
| 401.46 | 3.04 | 3.04 |
| 387.51 | 3.75 | 3.75 |
| 406.47 | 3.75 | 3.75 |
| 447.41 | 5.19 | 5.19 |
| 383.47 | 2.90 | 2.90 |
| 369.47 | 4.19 | 4.19 |
| 424.46 | 3.89 | 3.89 |
| 371.44 | 3.03 | 3.03 |
| 399.49 | 3.81 | 3.81 |
| 442.25 | 3.37 | 3.37 |
| 393.44 | 4.48 | 4.48 |
| 355.44 | 3.80 | 3.80 |
| 461.38 | 3.64 | 3.64 |
| 449.34 | 3.77 | 3.77 |
| 407.41 | 2.93 | 2.93 |
| 394.43 | 3.88 | 3.88 |
| 405.45 | 4.43 | 4.43 |
| 380.40 | 3.57 | 3.57 |
| 461.38 | 3.64 | 3.64 |
| 429.38 | 3.83 | 3.83 |
| 393.44 | 4.48 | 4.48 |
| 407.47 | 4.79 | 4.79 |
| 409.49 | 3.75 | 3.75 |
| 361.38 | 2.81 | 2.81 |
| 382.42 | 3.51 | 3.51 |
| 361.38 | 2.81 | 2.81 |