Basic Information
ID: ALA4310573
Type: Functional
Description: Negative allosteric modulation of human mGlu5 receptor assessed as inhibition of glutamate induced-calcium mobilization
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4310573
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 333.41 | 2.97 | 2.97 |
| 346.41 | 2.02 | 2.02 |
| 313.36 | 2.60 | 2.60 |
| 299.33 | 2.06 | 2.06 |
| 313.36 | 2.60 | 2.60 |
| 331.35 | 2.73 | 2.73 |
| 299.33 | 2.21 | 2.21 |
| 273.29 | 2.02 | 2.02 |
| 337.43 | 1.92 | 1.92 |
| 331.35 | 2.73 | 2.73 |
| 333.41 | 2.97 | 2.97 |
| 321.40 | 2.82 | 2.82 |
| 303.39 | 3.34 | 3.34 |
| 333.41 | 2.96 | 2.96 |
| 369.39 | 3.59 | 3.59 |
| 359.45 | 3.53 | 3.53 |
| 321.43 | 2.90 | 2.90 |
| 285.30 | 1.81 | 1.81 |
| 261.26 | 2.19 | 2.19 |
| 382.47 | 1.43 | 1.43 |
| 319.39 | 2.43 | 2.43 |
| 291.28 | 2.16 | 2.16 |
| 317.32 | 2.20 | 2.20 |
| 299.33 | 2.21 | 2.21 |
| 331.44 | 4.12 | 4.12 |
| 321.40 | 2.82 | 2.82 |
| 329.38 | 3.89 | 3.89 |
| 331.35 | 2.73 | 2.73 |
| 311.39 | 3.75 | 3.75 |
| 353.43 | 1.58 | 1.58 |
| 333.41 | 2.96 | 2.96 |
| 303.29 | 1.95 | 1.95 |
| 297.36 | 3.36 | 3.36 |
| 331.35 | 2.73 | 2.73 |
| 321.40 | 2.82 | 2.82 |
| 299.33 | 2.21 | 2.21 |
| 317.41 | 3.73 | 3.73 |
| 321.40 | 2.82 | 2.82 |
| 333.41 | 2.96 | 2.96 |
| 333.41 | 2.82 | 2.82 |
| 351.40 | 3.10 | 3.10 |
| 331.35 | 2.73 | 2.73 |
| 331.35 | 2.73 | 2.73 |
| 317.32 | 2.34 | 2.34 |
| 293.35 | 2.39 | 2.39 |
| 319.39 | 2.57 | 2.57 |
| 315.35 | 3.50 | 3.50 |
| 387.38 | 3.67 | 3.67 |
| 319.39 | 2.57 | 2.57 |
| 313.36 | 2.45 | 2.45 |
| 333.41 | 2.96 | 2.96 |
| 305.36 | 2.18 | 2.18 |
| 283.33 | 2.97 | 2.97 |
| 333.41 | 2.97 | 2.97 |
| 317.32 | 2.34 | 2.34 |
| 351.40 | 3.12 | 3.12 |
| 331.35 | 2.73 | 2.73 |
| 331.35 | 2.59 | 2.59 |
| 335.45 | 3.29 | 3.29 |
| 313.36 | 2.60 | 2.60 |
| 301.32 | 3.11 | 3.11 |
| 319.39 | 2.57 | 2.57 |
| 317.32 | 2.34 | 2.34 |