Basic Information
ID: ALA4311871
Type: Functional
Description: In vivo inhibition of NEP in Sprague-Dawley rat assessed as potentiation of ANP-induced elevation of urinary cGMP level at 3 mg/kg, iv treated for 5 mins at 15 mins post 2 doses of angiotensin-2 treatment at 15 minutes apart followed by ANP treatment measured up to 60 mins by EIA relative to control
Organism: Rattus norvegicus
Strain: Sprague-Dawley
Activity Charts
Bioactivity
Activity Types for Assay ALA4311871
FC
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 408.55 | 1.94 | 1.94 |
| 527.66 | 5.36 | 5.36 |
| 537.73 | 5.86 | 5.86 |
| 521.73 | 6.16 | 6.16 |
| 535.75 | 6.41 | 6.41 |
| 523.70 | 5.61 | 5.61 |
| 547.77 | 6.72 | 6.72 |
| 549.78 | 6.80 | 6.80 |
| 542.15 | 6.50 | 6.50 |
| 509.67 | 5.22 | 5.22 |
| 527.66 | 5.36 | 5.36 |
| 533.74 | 6.48 | 6.48 |
| 541.69 | 5.61 | 5.61 |
| 523.70 | 5.47 | 5.47 |