Inhibition of PI3K/AKT/mTOR in human lung fibroblasts assessed as reduction in AKT phosphorylation at serine473 residue preincubated for 1 hr followed...

Basic Information

ID: ALA4312793

Type: Binding

Description: Inhibition of PI3K/AKT/mTOR in human lung fibroblasts assessed as reduction in AKT phosphorylation at serine473 residue preincubated for 1 hr followed by PDGF-BB stimulation and measured after 10 mins by electrochemiluminescence method

Format: BAO_0000019

Organism: Homo sapiens

Target: Molecular identity unknown(ALA612546)

Document: ALA4311944

Inhibition of PI3K/AKT/mTOR in human lung fibroblasts assessed as reduction in AKT phosphorylation at serine473 residue preincubated for 1 hr followed by PDGF-BB stimulation and measured after 10 mins by electrochemiluminescence method: 1

Associated Items: Associated Bioactivities Associated Compounds

Activity Charts

Bioactivity

Activity Types for Assay ALA4312793

IC50

Total(36)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
433.53	2.05	2.05
493.66	1.93	1.93
419.51	1.67	1.67
461.59	1.81	1.81
363.44	1.62	1.62
490.65	2.38	2.38
458.58	2.26	2.26
433.53	1.07	1.07
271.32	2.07	2.07
338.41	2.96	2.96
360.44	2.07	2.07
256.30	2.74	2.74
388.49	2.81	2.81
341.42	2.51	2.51
430.53	2.51	2.51
338.41	2.96	2.96
388.49	2.81	2.81
458.58	3.24	3.24
327.39	2.12	2.12
430.53	2.51	2.51
391.49	2.35	2.35
338.41	2.96	2.96
268.32	2.53	2.53
257.29	1.69	1.69
458.58	3.24	3.24
324.38	3.09	3.09
254.29	2.65	2.65
268.32	2.53	2.53
268.32	2.53	2.53
490.65	2.38	2.38
430.53	1.52	1.52
430.53	1.52	1.52
461.59	2.79	2.79
360.44	2.07	2.07
346.41	2.20	2.20
458.58	2.26	2.26