Basic Information
ID: ALA4313161
Type: Binding
Description: Inhibition of ERCC1-XPF-mediated nucleotide excision repair in human HCT116 cells assessed as reduction in removal of UV-induced cyclobutane pyrimidine dimer by measuring cyclobutane pyrimidine dimer level at 2 uM incubated for 1 hr prior to compound washout followed by 8 J/m2 UV irradiation and subsequent compound addition and measured after 24 hrs by DAPI staining-based immunofluorescence assay (Rvb = 80%)
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4313161
Activity
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 520.08 | 5.18 | 5.18 |