Inhibition of recombinant HCV genotype 1a NS5B polymerase coincubated with HCV international ribosome entry site template sequence containing nucleoti...

Basic Information

ID: ALA4314448

Type: Binding

Description: Inhibition of recombinant HCV genotype 1a NS5B polymerase coincubated with HCV international ribosome entry site template sequence containing nucleotide residues 21-371 of HCV 5'-untranslated Escherichia coli DNA polymerase I region incubated for 3 hrs by scintillation/luminescence counter method

Format: BAO_0000357

Organism: Hepatitis C virus subtype 1a

Target: Hepatitis C virus NS5B RNA-dependent RNA polymerase(ALA5375)

Document: ALA4311989

Inhibition of recombinant HCV genotype 1a NS5B polymerase coincubated with HCV international ribosome entry site template sequence containing nucleotide residues 21-371 of HCV 5'-untranslated Escherichia coli DNA polymerase I region incubated for 3 hrs by scintillation/luminescence counter method: 1

Associated Items: Associated Bioactivities Associated Compounds

Activity Charts

Bioactivity

Activity Types for Assay ALA4314448

IC50

Total(76)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
407.28	4.67	4.67
463.58	5.58	5.58
372.83	4.02	4.02
368.41	3.37	3.37
407.28	4.67	4.67
372.83	4.02	4.02
338.39	3.36	3.36
390.30	3.10	3.10
420.32	3.11	3.11
385.88	2.46	2.46
441.72	5.32	5.32
390.30	3.10	3.10
369.42	1.94	1.94
390.30	3.10	3.10
402.86	4.02	4.02
386.40	3.51	3.51
351.43	1.80	1.80
407.28	4.67	4.67
355.85	2.45	2.45
437.30	4.68	4.68
413.50	4.80	4.80
385.88	2.46	2.46
351.43	1.80	1.80
402.86	4.02	4.02
402.86	4.02	4.02
280.35	3.74	3.74
372.83	4.02	4.02
355.85	2.45	2.45
356.38	3.50	3.50
373.84	2.59	2.59
368.41	3.37	3.37
381.46	1.81	1.81
390.82	4.15	4.15
398.44	3.38	3.38
385.88	2.46	2.46
339.40	1.93	1.93
355.85	2.45	2.45
424.74	3.75	3.75
321.41	1.79	1.79