Basic Information
ID: ALA4322927
Type: Binding
Description: Antagonist activity at BacMam virus expressing human TRPV4 transduced in BHK/AC9 or HEK MSR2 cells assessed as inhibition of GSK634775-induced Ca2+ flux preincubated for 10 mins followed by agonist addition by Fluo-4 AM dye based FLIPR assay
Format: BAO_0000219
Organism: Homo sapiens
Target: Transient receptor potential cation channel subfamily V member 4(ALA3119)
Document: ALA4321813
Antagonist activity at BacMam virus expressing human TRPV4 transduced in BHK/AC9 or HEK MSR2 cells assessed as inhibition of GSK634775-induced Ca2+ flux preincubated for 10 mins followed by agonist addition by Fluo-4 AM dye based FLIPR assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4322927
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 461.30 | 2.18 | 2.18 |
| 427.84 | 0.92 | 0.92 |
| 427.84 | 0.92 | 0.92 |
| 460.41 | 1.89 | 1.89 |
| 417.42 | 0.74 | 0.74 |
| 461.39 | 1.29 | 1.29 |
| 457.92 | 0.18 | 0.18 |
| 426.85 | 1.53 | 1.53 |
| 460.31 | 2.15 | 2.15 |
| 491.37 | 1.44 | 1.44 |
| 426.86 | 0.89 | 0.89 |